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KCNE1 Matched Antibody Pair (656) (APMAB-656LY)

This antibody pair set can be used for detecting and quantifying protein level of human KCNE1.
See all KCNE1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-KCNE1 polyclonal antibody, 100 ug
Detection Antibody
Anti-KCNE1 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Alternative Names
Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 1; Potassium Channel, Voltage Gated Subfamily E Regulatory Beta Subunit 1; IKs Producing Slow Voltage-Gated Potassium Channel Subunit Beta Mink; Potassium Voltage-Gated Channel, Isk-Related Family, Member 1; Delayed Rectifier Potassium Channel Subunit IsK; Minimal Potassium Channel; Potassium Voltage-Gated Channel, Isk-Related Subfamily, Member 1; Potassium Voltage-Gated Channel Subfamily E Member 1; Cardiac Delayed Rectifier Potassium Channel Protein;
Entrez Gene ID
3753
UniProt ID
P15382

Zou, X., Wu, X., Sampson, K. J., Colecraft, H. M., Larsson, H. P., & Kass, R. S. (2022). Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels. Frontiers in physiology, 13, 2415.

Prado, P. Á., Häfner, S., Comoglio, Y., Wdziekonski, B., Duranton, C., Attali, B., ... & Sandoz, G. (2021). KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies. Cell, 184(2), 534-544.

Kuenze, G., Vanoye, C. G., Desai, R. R., Adusumilli, S., Brewer, K. R., Woods, H., ... & Meiler, J. (2020). Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation. Elife, 9, e57680.

Wu, X., & Larsson, H. P. (2020). Insights into cardiac IKs (KCNQ1/KCNE1) channels regulation. International journal of molecular sciences, 21(24), 9440.

Wang, Y., Eldstrom, J., & Fedida, D. (2020). Gating and regulation of KCNQ1 and KCNQ1+ KCNE1 channel complexes. Frontiers in Physiology, 11, 504.

Xu Parks, X., Qudsi, H., Braun, C., & Lopes, C. M. (2020). The auxiliary subunit KCNE1 regulates KCNQ1 channel response to sustained calcium-dependent PKC activation. Plos one, 15(8), e0237591.

Faridi, R., Tona, R., Brofferio, A., Hoa, M., Olszewski, R., Schrauwen, I., ... & Friedman, T. B. (2019). Mutational and phenotypic spectra of KCNE1 deficiency in Jervell and Lange‐Nielsen syndrome and Romano‐Ward syndrome. Human mutation, 40(2), 162-176.

Thompson, E., Eldstrom, J., Westhoff, M., McAfee, D., & Fedida, D. (2018). The IKs channel response to cAMP is modulated by the KCNE1: KCNQ1 stoichiometry. Biophysical Journal, 115(9), 1731-1740.

Larsson, J. E., Larsson, H. P., & Liin, S. I. (2018). KCNE1 tunes the sensitivity of KV7. 1 to polyunsaturated fatty acids by moving turret residues close to the binding site. Elife, 7, e37257.

Yao, H., Ji, C. C., Cheng, Y. J., Chen, X. M., Liu, L. J., Fan, J., & Wu, S. H. (2018). Mutation in KCNE1 associated to early repolarization syndrome by modulation of slowly activating delayed rectifier K+ current. Experimental Cell Research, 363(2), 315-320.

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For research use only. Not intended for any clinical use.

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