MICA Matched Antibody Pair (735) (APMAB-735LY)

Name: MICA Matched Antibody Pair (735)
SKU: APMAB-735LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-MICA polyclonal antibody, 100 ug

Detection Antibody

Anti-MICA Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Alternative Names

MHC Class I Polypeptide-Related Sequence A; PERB11.1; MIC-A; Truncated MHC Class I Polypeptide-Related Sequence A; MHC Class I Chain-Related Protein A; Stress Inducible Class I Homolog; MHC Class I Related Sequence A; MHC Class I Related Chain A; HLA Class I Antigen;

Entrez Gene ID

4276

UniProt ID

Q29983

More Infomation

Ren, X., Mao, A., Tan, S., Liu, J., & Wei, X. (2022). Analysis of the association between MICA gene polymorphisms and schizophrenia. Journal of Clinical Laboratory Analysis, 36(11), e24721.

Espinoza, I., Agarwal, S., Sakiyama, M., Shenoy, V., Orr, W. S., Al Diffalha, S., ... & Gomez, C. R. (2021). Expression of MHC class I polypeptide-related sequence A (MICA) in colorectal cancer.

Closa, L., Vidal, F., Herrero, M. J., & Caro, J. L. (2021). High‐throughput genotyping of HLA‐G, HLA‐F, MICA, and MICB and analysis of frequency distributions in healthy blood donors from Catalonia. HLA, 97(5), 420-427.

Otoyama, Y., Arai, J., Goto, K., Nozawa, H., Nakagawa, R., Muroyama, R., ... & Yoshida, H. (2021). Retinoids decrease soluble MICA concentration by inhibiting the enzymatic activity of ADAM9 and ADAM10. Anticancer Research, 41(5), 2307-2320.

Gong, X., Chen, P., Ma, P., Gao, J., Yang, J., Guo, H., ... & He, Y. (2020). MICA polymorphisms associated with antithyroid drug‐induced agranulocytosis in the Chinese Han population. Immunity, Inflammation and Disease, 8(4), 695-703.

Plasil, M., Wijkmark, S., Elbers, J. P., Oppelt, J., Burger, P. A., & Horin, P. (2019). The major histocompatibility complex of Old World camelids: class I and class I‐related genes. Hla, 93(4), 203-215.

Sakiyama, M. J., Espinoza, I., Reddy, A., de Carlo, F., Kumar, A., Levenson, A. S., ... & Gomez, C. R. (2019). Race-associated expression of MHC class I polypeptide-related sequence A (MICA) in prostate cancer. Experimental and molecular pathology, 108, 173-182.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant MICA protein, ECD, His Tag (CAT#: V2LY-0526-LY1604)

Human Recombinant MICA*018 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5578)

Human Recombinant MICA*018 protein, ECD, His Tag (CAT#: V2LY-0526-LY5579)

Human Recombinant MICA*00801 protein, His Tag (CAT#: V2LY-0526-LY5580)

Related Products

Mouse Anti-MICA Recombinant Antibody (CBFYM-0060) (CAT#: CBMAB-M0068-FY)

Mouse Anti-MICA Recombinant Antibody (A1090) (CAT#: CBMAB-AP11855LY)

Mouse Anti-MICA Recombinant Antibody (CBFYM-0792) (CAT#: CBMAB-M0936-FY)

Cynomolgus Recombinant MICA protein, ECD, His Tag (CAT#: V2LY-0526-LY1604)

Mouse Anti-MICA (AA 23-308) Recombinant Antibody (CBFYM-2204) (CAT#: CBMAB-M2387-FY)

Human Recombinant MICA*018 protein, ECD, His Tag (CAT#: V2LY-0526-LY5579)

Mouse Anti-MICA Recombinant Antibody (CBFYM-0003) (CAT#: CBMAB-M0004-FY)

Human Recombinant MICA*018 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5578)

Human Recombinant MICA*00801 protein, His Tag (CAT#: V2LY-0526-LY5580)

Mouse Anti-MICA (AA 1-308) Recombinant Antibody (CBFYM-2207) (CAT#: CBMAB-M2390-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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