Mouse Anti-ACVRL1 Recombinant Antibody (V2-12519) (CBMAB-1009-CN)

Name: Mouse Anti-ACVRL1 Recombinant Antibody (V2-12519)
SKU: CBMAB-1009-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-12519

Application

IHC, WB

Immunogen

Human ACVRL1 extra-cellular domain.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:200-1:800
IHC-P	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Activin A Receptor Like Type 1

Introduction

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, it forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

Entrez Gene ID

UniProt ID

P37023

Alternative Names

HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1

Function

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Biological Process

Angiogenesis
Artery development
Blood circulation
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Blood vessel maturation
Blood vessel remodeling
BMP signaling pathway
Cellular response to BMP stimulus
Cellular response to growth factor stimulus
Cellular response to transforming growth factor beta stimulus
Dorsal/ventral pattern formation
Dorsal aorta morphogenesis
Endocardial cushion morphogenesis
Endothelial tube morphogenesis
Heart development
Lymphangiogenesis
Lymphatic endothelial cell differentiation
Negative regulation of blood vessel endothelial cell migration
Negative regulation of cell adhesion
Negative regulation of cell growth
Negative regulation of cell migration
Negative regulation of cell population proliferation
Negative regulation of DNA biosynthetic process
Negative regulation of endothelial cell migration
Negative regulation of focal adhesion assembly
Negative regulation of gene expression
Positive regulation of BMP signaling pathway
Positive regulation of chondrocyte differentiation
Positive regulation of pathway-restricted SMAD protein phosphorylation
Positive regulation of transcription, DNA-templated
Positive regulation of transcription by RNA polymerase II
Protein phosphorylation
Regulation of blood pressure
Regulation of blood vessel endothelial cell migration
Regulation of DNA replication
Regulation of endothelial cell proliferation
Regulation of transcription, DNA-templated
Retina vasculature development in camera-type eye
Signal transduction
Transforming growth factor beta receptor signaling pathway
Venous blood vessel development
Wound healing, spreading of epidermal cells

Cellular Location

Cell membrane

Involvement in disease

Telangiectasia, hereditary hemorrhagic, 2 (HHT2): A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain.

Topology

Extracellular: 22-118 aa
Helical: 119-141 aa
Cytoplasmic: 142-503 aa

Toyonaga, T., Steinbach, E. C., Keith, B. P., Barrow, J. B., Schaner, M. R., Wolber, E. A., ... & Sheikh, S. Z. (2020). Decreased colonic Activin receptor-like kinase 1 disrupts epithelial barrier integrity in patients with Crohn’s disease. Cellular and molecular gastroenterology and hepatology, 10(4), 779-796.

Anderson, K. E., Bellio, T. A., Aniskovich, E., Adams, S. L., Blusztajn, J. K., & Delalle, I. (2020). The Expression of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) in Hippocampal Arterioles Declines During Progression of Alzheimer’s Disease. Cerebral cortex communications, 1(1), tgaa031.

Mamoor, S. (2020). The Activin-A receptor-like protein 1, ACVRL1 is differentially expressed in non-small cell lung cancer.

Hwan Kim, Y., Vu, P. N., Choe, S. W., Jeon, C. J., Arthur, H. M., Vary, C. P., ... & Oh, S. P. (2020). Overexpression of activin receptor-like kinase 1 in endothelial cells suppresses development of arteriovenous malformations in mouse models of hereditary hemorrhagic telangiectasia. Circulation research, 127(9), 1122-1137.

Bocci, M., Sjölund, J., Kurzejamska, E., Lindgren, D., Bartoschek, M., Höglund, M., & Pietras, K. (2019). Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer. Angiogenesis, 22(1), 117-131.

Adams, S. L., Benayoun, L., Tilton, K., Mellott, T. J., Seshadri, S., Blusztajn, J. K., & Delalle, I. (2018). Immunohistochemical analysis of activin receptor-like kinase 1 (ACVRL1/ALK1) expression in the rat and human hippocampus: Decline in CA3 during progression of Alzheimer’s disease. Journal of Alzheimer's Disease, 63(4), 1433-1443.

Claesson-Welsh, L. (2018). Alk1 (Activin Receptor-Like Kinase 1) and Vascular Hyperpermeability in Diabetic Retinopathy: More Is Less.

Busceti, C. L., Marchitti, S., Bianchi, F., Di Pietro, P., Riozzi, B., Stanzione, R., ... & Rubattu, S. (2017). Dickkopf-3 upregulates VEGF in cultured human endothelial cells by activating activin receptor-like kinase 1 (ALK1) pathway. Frontiers in pharmacology, 8, 111.

Roman, B. L., & Hinck, A. P. (2017). ALK1 signaling in development and disease: new paradigms. Cellular and Molecular Life Sciences, 74(24), 4539-4560.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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