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Mouse Anti-AIMP2 Recombinant Antibody (V2-180360) (CBMAB-A1822-YC)

Provided herein is a Mouse monoclonal antibody against Human Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all AIMP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180360
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
JTV1 (NP_006294.2, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2
Introduction
AIMP2 is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the com
Entrez Gene ID
7965
UniProt ID
Q13155
Alternative Names
Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2; Multisynthase Complex Auxiliary Component P38; Protein JTV-1; JTV1; Aminoacyl TRNA Synthase Complex-Interacting Multifunctional Protein 2; Multisynthetase Complex Auxiliary Component
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: Ensembl
Positive regulation of aminoacyl-tRNA ligase activity Source: GO_Central
Positive regulation of neuron death Source: Ensembl
Positive regulation of protein ubiquitination Source: Ensembl
Protein-containing complex assembly Source: Ensembl
tRNA aminoacylation for protein translation Source: Reactome
Type II pneumocyte differentiation Source: Ensembl
Cellular Location
Cytosol; Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Involvement in disease
Leukodystrophy, hypomyelinating, 17 (HLD17): An autosomal recessive neurodevelopmental disorder characterized by atrophy of cerebral cortex, spinal cord and cerebellum, thin corpus callosum, abnormal signals in the basal ganglia, and features suggesting hypo- or demyelination observed on brain imaging. Clinical manifestations include lack of development, absent speech, microcephaly, spasticity, seizures, and contractures.
PTM
Phosphorylated on serine residues in response to UV irradiation.
Ubiquitinated by PRKN, leading to its degradation by the proteasome. Mutant PRKN fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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