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Mouse Anti-AIMP2 Recombinant Antibody (V2-11278) (CBMAB-0027-FY)

This product is mouse antibody that recognizes AIMP2. The antibody CBFYA-001 can be used for immunoassay techniques such as: WB, S-ELISA, ELISA.
See all AIMP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
V2-11278
Antibody Isotype
IgG2b, κ
Application
WB, IHC

Basic Information

Immunogen
JTV1 fusion protein.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000-1:10,000
IHC1:250-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-100

Target

Full Name
Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2
Introduction
AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) encodes the protein which is part of the aminoacyl-tRNA synthetase complex. Diseases associated with AIMP2 include Leukodystrophy, Hypomyelinating, 3.
Entrez Gene ID
7965
UniProt ID
Q13155
Alternative Names
P38; JTV1; JTV-1
Function
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: Ensembl
Positive regulation of aminoacyl-tRNA ligase activity Source: GO_Central
Positive regulation of neuron death Source: Ensembl
Positive regulation of protein ubiquitination Source: Ensembl
Protein-containing complex assembly Source: Ensembl
tRNA aminoacylation for protein translation Source: Reactome
Type II pneumocyte differentiation Source: Ensembl
Cellular Location
Cytosol; Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
Involvement in disease
Leukodystrophy, hypomyelinating, 17 (HLD17): An autosomal recessive neurodevelopmental disorder characterized by atrophy of cerebral cortex, spinal cord and cerebellum, thin corpus callosum, abnormal signals in the basal ganglia, and features suggesting hypo- or demyelination observed on brain imaging. Clinical manifestations include lack of development, absent speech, microcephaly, spasticity, seizures, and contractures.
PTM
Phosphorylated on serine residues in response to UV irradiation.
Ubiquitinated by PRKN, leading to its degradation by the proteasome. Mutant PRKN fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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