Mouse Anti-GPAT3 Recombinant Antibody (CBLG1-187) (V2LY-0226-LY646)

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Basic Information

Host Animal
Mouse
Clone
CBLG1-187
Application
WB
Immunogen
Human recombinant protein fragment corresponding to amino acids 41-131 of human GPAT3.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, BSA, glycerol
Preservative
Sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 3
Entrez Gene ID
UniProt ID
Function
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (PubMed:17170135).

Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:19318427).
Biological Process
CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Glycerol-3-phosphate metabolic process Source: Ensembl
Phosphatidic acid biosynthetic process Source: Reactome
Regulation of TOR signaling Source: UniProtKB
Triglyceride biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane

Fan, G., Li, Y., Zong, Y., Suo, X., Jia, Y., Gao, M., & Yang, X. (2023). GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway. Cell Death & Disease, 14(3), 208.

Song, J., Zhao, H., Zhang, L., Li, Z., Han, J., Zhou, C., ... & Yan, X. (2023). The heat shock transcription factor PtHSF1 mediates triacylglycerol and fucoxanthin synthesis by regulating the expression of GPAT3 and DXS in Phaeodactylum tricornutum. Plant and Cell Physiology, pcad023.

Ma, C., Sun, Y., Wang, J., Kang, L., & Jiang, Y. (2022). Identification of a promoter polymorphism affecting GPAT3 gene expression that is likely related to intramuscular fat content in pigs. Animal Biotechnology, 33(6), 1378-1381.

Tanigawa, K., Hayashi, Y., Hama, K., Yamashita, A., Yokoyama, K., Luo, Y., ... & Suzuki, K. (2021). Mycobacterium leprae promotes triacylglycerol de novo synthesis through induction of GPAT3 expression in human premonocytic THP-1 cells. PLoS One, 16(3), e0249184.

Sim, M. F., Persiani, E., Talukder, M., Uddin, M., Mcilroy, G. D., Roumane, A., ... & Rochford, J. J. (2020). Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation. Scientific Reports, 10(1), 1-14.

Gao, M., Liu, L., Wang, X., Mak, H. Y., Liu, G., & Yang, H. (2020). GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Human molecular genetics, 29(3), 432-443.

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For research use only. Not intended for any clinical use.

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