Mouse Anti-GPR157 Recombinant Antibody (EG1387) (V2LY-0226-LY846)

Name: Mouse Anti-GPR157 Recombinant Antibody (EG1387)
SKU: V2LY-0226-LY846
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

EG1387

Application

FC, IF

Immunogen

Human GPR158 protein (Ala24-Gln411).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

G protein-coupled receptor 157

Entrez Gene ID

80045

UniProt ID

Q5UAW9

Function

Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.

Biological Process

Cell surface receptor signaling pathway Source: InterPro
Circadian behavior Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Radial glial cell differentiation Source: UniProtKB

Cellular Location

Cilium membrane. Expressed in the primary cilia of radial glial progenitors (RGPs) exposed to the cerebrospinal fluid.

Topology

Extracellular: 1-15
Helical: 16-36
Cytoplasmic: 37-48
Helical: 49-69
Extracellular: 70-87
Helical: 88-108
Cytoplasmic: 109-119
Helical: 120-140
Extracellular: 141-166
Helical: 167-187
Cytoplasmic: 188-226
Helical: 227-247
Extracellular: 248-258
Helical: 259-279
Cytoplasmic: 280-335

Guo, H., Du, X., Zhang, Y., Wu, J., Wang, C., Li, M., ... & Yan, J. (2019). Specific miRNA-G protein-coupled receptor networks regulate Sox9a/Sox9b activities to promote gonadal rejuvenation in zebrafish. Stem Cells, 37(9), 1189-1199.

Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., ... & CGTP Collaborators. (2019). The Concise Guide to PHARMACOLOGY 2019/20: G protein-coupled receptors. British Journal of Pharmacology, 176(Suppl 1).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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