Mouse Adamts4 ELISA Kit (V2LY-0626-LY1788)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
2.91 ng/mL
Detection Range
5-300 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
90.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4
Function
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Biological Process
Extracellular matrix disassembly
Extracellular matrix organization
Proteolysis
Skeletal system development
Cellular Location
Extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).

Li, L., Ma, W., Pan, S., Li, Y., Wang, H., Wang, B., & Khalil, R. A. (2020). MiR‐126a‐5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS‐4 expression. Journal of cellular and molecular medicine, 24(14), 7896-7906.

Rogerson, F. M., Last, K., Golub, S. B., Gauci, S. J., Stanton, H., Bell, K. M., & Fosang, A. J. (2019). ADAMTS-9 in mouse cartilage has aggrecanase activity that is distinct from ADAMTS-4 and ADAMTS-5. International journal of molecular sciences, 20(3), 573.

Chen, J., Luo, Y., Zhou, Y., Qin, S., Qiu, Y., Cui, R., ... & Zhong, M. (2018). Promotion of tumor growth by ADAMTS4 in colorectal cancer: focused on macrophages. Cellular Physiology and Biochemistry, 46(4), 1693-1703.

Ren, P., Hughes, M., Krishnamoorthy, S., Zou, S., Zhang, L., Wu, D., ... & Shen, Y. H. (2017). Critical role of ADAMTS-4 in the development of sporadic aortic aneurysm and dissection in mice. Scientific reports, 7(1), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Adamts4 ELISA Kit (CAT#: V2LY-0626-LY1886)

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Rat Adamts4 ELISA Kit (CAT#: V2LY-0626-LY1886)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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