Mouse Gsn ELISA Kit (V2LY-0626-LY1099)

Name: Mouse Gsn ELISA Kit
SKU: V2LY-0626-LY1099
Rating: 5 (1 reviews)

See all Gsn antibodies

Compare Online Inquiry

Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

5.16 ng/mL

Detection Range

10-2000 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Mouse

Assay Type

Sandwich

Reactivity

Mouse

Assay Time

1.5 h

Molecule Mass

85.9 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Gelsolin

Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

Biological Process

Actin filament capping Source: UniProtKB
Actin filament depolymerization Source: BHF-UCL
Actin filament polymerization Source: UniProtKB
Actin filament reorganization Source: UniProtKB
Actin filament severing Source: UniProtKB
Actin nucleation Source: InterPro
Actin polymerization or depolymerization Source: GO_Central
Amyloid fibril formation Source: UniProtKB
Barbed-end actin filament capping Source: GO_Central
Cardiac muscle cell contraction Source: BHF-UCL
Cell projection assembly Source: GO_Central
Cellular response to interferon-gamma Source: Ensembl
Central nervous system development Source: GO_Central
Cilium assembly Source: UniProtKB
Hepatocyte apoptotic process Source: UniProtKB
Negative regulation of viral entry into host cell Source: UniProtKB
Phagocytosis, engulfment Source: UniProtKB
Positive regulation of actin nucleation Source: UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of keratinocyte apoptotic process Source: UniProtKB
Positive regulation of protein processing in phagocytic vesicle Source: UniProtKB
Protein destabilization Source: UniProtKB
Regulation of establishment of T cell polarity Source: UniProtKB
Regulation of plasma membrane raft polarization Source: UniProtKB
Regulation of podosome assembly Source: UniProtKB
Regulation of receptor clustering Source: UniProtKB
Relaxation of cardiac muscle Source: BHF-UCL
Renal protein absorption Source: UniProtKB
Response to muscle stretch Source: BHF-UCL
Sequestering of actin monomers Source: UniProtKB
Striated muscle atrophy Source: UniProtKB

Cellular Location

Isoform 2: Cytoskeleton
Isoform 1: Secreted

Involvement in disease

Amyloidosis 5 (AMYL5):
A hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

PTM

Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.

Zhang, Q., Tang, S. L., Zhao, Z. W., & Tang, C. K. (2023). Role and therapeutic potential of gelsolin in atherosclerosis. Journal of Molecular and Cellular Cardiology.

Onuma, T., Asare-Werehene, M., Yoshida, Y., & Tsang, B. K. (2022). Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance. Cells, 11(20), 3305.

Wu, Y., Zheng, J., Yan, Y., Liu, J., & Zhou, Y. (2022). Gelsolin can be a prognostic biomarker and correlated with immune infiltrates in gastric cancer. International Journal of General Medicine, 927-936.

Feldt, J., Schicht, M., Welss, J., Gelse, K., Sesselmann, S., Tsokos, M., ... & Paulsen, F. (2022). Production and secretion of gelsolin by both human macrophage-and fibroblast-like synoviocytes and GSN modulation in the synovial fluid of patients with various forms of arthritis. Biomedicines, 10(3), 723.

Potrč, M., Volk, M., de Rosa, M., Pižem, J., Teran, N., Jaklič, H., ... & Fakin, A. (2021). Clinical and histopathological features of gelsolin amyloidosis associated with a novel GSN variant p. Glu580Lys. International journal of molecular sciences, 22(3), 1084.

Jana, S., Aujla, P., Hu, M., Kilic, T., Zhabyeyev, P., McCulloch, C. A., ... & Kassiri, Z. (2021). Gelsolin is an important mediator of Angiotensin II‐induced activation of cardiac fibroblasts and fibrosis. The FASEB Journal, 35(10), e21932.

Zhang, Y., Luo, X., Lin, J., Fu, S., Feng, P., Su, H., ... & Deng, W. (2020). Gelsolin promotes cancer progression by regulating epithelial-mesenchymal transition in hepatocellular carcinoma and correlates with a poor prognosis. Journal of Oncology, 2020.

Chen, Z., Li, K., Yin, X., Li, H., Li, Y., Zhang, Q., ... & Qiu, Y. (2019). Lower expression of gelsolin in colon cancer and its diagnostic value in colon cancer patients. Journal of Cancer, 10(5), 1288.

Wittmann, J., Dieckow, J., Schröder, H., Hampel, U., Garreis, F., Jacobi, C., ... & Schicht, M. (2018). Plasma gelsolin promotes re-epithelialization. Scientific Reports, 8(1), 13140.

Feldt, J., Schicht, M., Garreis, F., Welss, J., Schneider, U. W., & Paulsen, F. (2018). Structure, regulation and related diseases of the actin-binding protein gelsolin. Expert reviews in molecular medicine, 20, e7.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Gsn ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human GSN ELISA Kit (CAT#: V2LY-0626-LY1509)

Cattle GSN ELISA Kit (CAT#: V2LY-0626-LY2292)

GSN Matched Antibody Pair (506) (CAT#: APMAB-506LY)

Antibody Pairs

GSN Matched Antibody Pair (506) (CAT#: APMAB-506LY)

Related Products

Alpaca Anti-GSN Recombinant VHH Antibody (6A2) (CAT#: CBMAB-1302CQ)

Mouse Anti-GSN Recombinant Antibody (CBLG1-256) (CAT#: CBMAB-G0871-LY)

Rabbit Anti-GSN Recombinant Antibody (8) (CAT#: CBMAB-G5278-LY)

Rat Anti-GSN Recombinant Antibody (CBLG1-3214) (CAT#: CBMAB-G5282-LY)

GSN Matched Antibody Pair (506) (CAT#: APMAB-506LY)

Human GSN ELISA Kit (CAT#: V2LY-0626-LY1509)

Mouse Anti-GSN Recombinant Antibody (CBT2926) (CAT#: V2LY-0625-LY1507)

Mouse Anti-GSN Recombinant Antibody (CBLG1-1906) (CAT#: CBMAB-G5285-LY)

Rabbit Anti-GSN Recombinant Antibody (AP2629) (CAT#: V2LY-0226-LY1689)

Mouse Anti-GSN Recombinant Antibody (205) (CAT#: CBMAB-G0869-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry