Mouse Recombinant CCL1 protein, hFc Tag (V2LY-0526-LY8411)

Name: Mouse Recombinant CCL1 protein, hFc Tag
SKU: V2LY-0526-LY8411
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

hFc Tag

Protein Construction

This product is Mouse Recombinant CCL1 protein, hFc Tag consist of Amino Acid: 24-92 and predicts a molecular mass of 36.2 kDa.

Molecule Mass

36.2 kDa

Sequence

Amino Acid: 24-92

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>92% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

chemokine (C-C motif) ligand 1

Function

Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: CAFA
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of interleukin-17 production Source: BHF-UCL
Positive regulation of monocyte chemotaxis Source: CAFA
Signal transduction Source: ProtInc
Viral process Source: ProtInc

Cellular Location

Secreted

Fujikawa, M., Koma, Y. I., Hosono, M., Urakawa, N., Tanigawa, K., Shimizu, M., ... & Yokozaki, H. (2021). Chemokine (CC Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway. The American Journal of Pathology, 191(4), 686-703.

García‐Domínguez, M., González‐Rodríguez, S., Hidalgo, A., Baamonde, A., & Menéndez, L. (2021). Kappa‐opioid receptor‐mediated thermal analgesia evoked by the intrathecal administration of the chemokine CCL1 in mice. Fundamental & Clinical Pharmacology.

Ding, S., Li, H., Li, X., Wang, W., Du, X., Dong, G., & Zhang, P. (2021). Retracted “Serum amyloid P down-regulates CCL-1 expression, and inhibits Ras/MAPK signaling and development of breast cancer”. Tropical Journal of Pharmaceutical Research, 20(10), 2235-2235.

Komatsu, M., Yamamoto, H., Yasuo, M., Ushiki, A., Nakajima, T., Uehara, T., ... & Hanaoka, M. (2020). The utility of serum CC chemokine ligand 1 in sarcoidosis: A comparison to IgG4-related disease. Cytokine, 133, 155123.

Zhong, L., Xiao, W., Wang, F., Liu, J., & Zhi, L. J. (2019). miR‐21‐5p inhibits neuropathic pain development via directly targeting C‐C motif ligand 1 and tissue inhibitor of metalloproteinase‐3. Journal of cellular biochemistry, 120(10), 16614-16623.

Yamamoto, H., Yasuo, M., Komatsu, M., Ushiki, A., Hamano, H., Hori, A., ... & Hanaoka, M. (2019). Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis. Cytokine, 120, 125-129.

García-Domínguez, M., Aguirre, A., Lastra, A., Hidalgo, A., Baamonde, A., & Menéndez, L. (2019). The Systemic administration of the chemokine CCL1 evokes thermal analgesia in mice through the activation of the endocannabinoid system. Cellular and molecular neurobiology, 39(8), 1115-1124.

Ding, S., Li, H., Li, X., Wang, W., Du, X., Dong, G., & Zhang, P. (2017). Serum amyloid P down-regulates CCL-1 expression, and inhibits Ras/MAPK signaling and development of breast cancer. Tropical Journal of Pharmaceutical Research, 16(9), 2089-2095.

Saito, M., Sejima, H., Naito, T., Ushirogawa, H., Matsuzaki, T., Matsuura, E., ... & Takashima, H. (2017). The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. Virology journal, 14(1), 1-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CCL1 protein (CAT#: V2LY-0526-LY4616)

Human Recombinant CCL1 protein, hFc Tag (CAT#: V2LY-0526-LY4617)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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