Mouse Recombinant CD93 protein, hFc Tag (V2LY-0526-LY7891)

Name: Mouse Recombinant CD93 protein, hFc Tag
SKU: V2LY-0526-LY7891
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

hFc Tag

Protein Construction

This product is Mouse Recombinant CD93 protein, hFc Tag consist of Amino Acid: 1-572 and predicts a molecular mass of 85.83 kDa.

Molecule Mass

85.83 kDa

Verified

HPLC

Sequence

Amino Acid: 1-572

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

CD93 molecule

Function

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Biological Process

Cell-cell adhesion Source: UniProtKB
Macrophage activation Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phagocytosis Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Membrane

Topology

Extracellular: 24-580
Helical: 581-601
Cytoplasmic: 602-652

PTM

N- and O-glycosylated.

Sun, Y., Chen, W., Torphy, R. J., Yao, S., Zhu, G., Lin, R., ... & Zhu, Y. (2021). Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science translational medicine, 13(604), eabc8922.

Barbera, S., Raucci, L., Lugano, R., Tosi, G. M., Dimberg, A., Santucci, A., ... & Orlandini, M. (2021). CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells. International Journal of Molecular Sciences, 22(22), 12417.

Barbera, S., Lugano, R., Pedalina, A., Mongiat, M., Santucci, A., Tosi, G. M., ... & Orlandini, M. (2021). The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases. Matrix Biology.

Kinstrie, R., Horne, G. A., Morrison, H., Irvine, D., Munje, C., Castañeda, E. G., ... & Copland, M. (2020). CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), 1613-1625.

Tosi, G. M., Neri, G., Barbera, S., Mundo, L., Parolini, B., Lazzi, S., ... & Orlandini, M. (2020). The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization. Investigative ophthalmology & visual science, 61(8), 30-30.

Barbera, S., Nardi, F., Elia, I., Realini, G., Lugano, R., Santucci, A., ... & Orlandini, M. (2019). The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration. Cell Communication and Signaling, 17(1), 1-15.

Lugano, R., Vemuri, K., Yu, D., Bergqvist, M., Smits, A., Essand, M., ... & Dimberg, A. (2018). CD93 promotes β 1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. The Journal of clinical investigation, 128(8), 3280-3297.

Griffiths, M. R., Botto, M., Morgan, B. P., Neal, J. W., & Gasque, P. (2018). CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis. Immunology, 155(3), 346-355.

Galvagni, F., Nardi, F., Spiga, O., Trezza, A., Tarticchio, G., Pellicani, R., ... & Orlandini, M. (2017). Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium. Matrix Biology, 64, 112-127.

Khan, K. A., Naylor, A. J., Khan, A., Noy, P. J., Mambretti, M., Lodhia, P., ... & Bicknell, R. (2017). Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface. Oncogene, 36(44), 6097-6108.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CD93 protein, hFc Tag (CAT#: V2LY-0526-LY2455)

Human Recombinant CD93 protein, His Tag (CAT#: V2LY-0526-LY2456)

Mouse Recombinant CD93 protein, ECD, His Tag (CAT#: V2LY-0526-LY7890)

Rat Recombinant CD93 protein, His Tag (CAT#: V2LY-0526-LY9188)

Rhesus Recombinant CD93 protein, His Tag (CAT#: V2LY-0526-LY9653)

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Rhesus Recombinant CD93 protein, His Tag (CAT#: V2LY-0526-LY9653)

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Mouse Recombinant CD93 protein, ECD, His Tag (CAT#: V2LY-0526-LY7890)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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