Mouse Recombinant CTSA protein, His Tag (V2LY-0526-LY7920)

Name: Mouse Recombinant CTSA protein, His Tag
SKU: V2LY-0526-LY7920
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant CTSA protein, His Tag consist of Amino Acid: 1-474 and predicts a molecular mass of 52.8 kDa.

Molecule Mass

52.8 kDa

Sequence

Amino Acid: 1-474

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>96% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cathepsin A

Function

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.

Biological Process

Glycosphingolipid metabolic process Source: Reactome
Intracellular protein transport Source: ProtInc
Negative regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Neutrophil degranulation Source: Reactome
Proteolysis Source: ParkinsonsUK-UCL
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of protein stability Source: ParkinsonsUK-UCL

Cellular Location

Lysosome

Involvement in disease

Galactosialidosis (GSL):
A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival.

Wang, H., Xu, F., Yang, F., Lv, L., & Jiang, Y. (2021). Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma. Scientific Reports, 11(1), 1-15.

Park, S., Kwon, W., Park, J. K., Baek, S. M., Lee, S. W., Cho, G. J., ... & Choi, S. K. (2020). Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer. Archives of Biochemistry and Biophysics, 688, 108407.

Hu, B., Zhu, X., & Lu, J. (2020). Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells. Molecular Medicine Reports, 21(6), 2553-2559.

Kim, J. W., Mahiddine, F. Y., & Kim, G. A. (2020). Leptin modulates the metastasis of canine inflammatory mammary adenocarcinoma cells through downregulation of lysosomal protective protein cathepsin a (Ctsa). International journal of molecular sciences, 21(23), 8963.

Toss, M. S., Miligy, I. M., Haj‐Ahmad, R., Gorringe, K. L., AlKawaz, A., Mittal, K., ... & Rakha, E. A. (2019). The prognostic significance of lysosomal protective protein (cathepsin A) in breast ductal carcinoma in situ. Histopathology, 74(7), 1025-1035.

Nakajima, H., Ueno, M., Adachi, K., Nanba, E., Narita, A., Tsukimoto, J., ... & Kawakami, A. (2019). A new heterozygous compound mutation in the CTSA gene in galactosialidosis. Human genome variation, 6(1), 1-5.

Ni, S., Weng, W., Xu, M., Wang, Q., Tan, C., Sun, H., ... & Sheng, W. (2018). miR-106b-5p inhibits the invasion and metastasis of colorectal cancer by targeting CTSA. OncoTargets and therapy, 11, 3835.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CTSA protein, His Tag (CAT#: V2LY-0526-LY2602)

Human CTSA ELISA Kit (CAT#: V2LY-0626-LY4845)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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