Mouse Recombinant FABP4 protein, His Tag (V2LY-0526-LY8286)

Name: Mouse Recombinant FABP4 protein, His Tag
SKU: V2LY-0526-LY8286
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant FABP4 protein, His Tag consist of Amino Acid: 1-132 and predicts a molecular mass of 16 kDa.

Molecule Mass

16 kDa

Sequence

Amino Acid: 1-132

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fatty Acid Binding Protein 4

Research Area

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.

Biological Process

Brown fat cell differentiation Source: Ensembl
Cellular response to lithium ion Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Cholesterol homeostasis Source: Ensembl
Long-chain fatty acid transport Source: UniProtKB
Negative regulation of protein kinase activity Source: Ensembl
Negative regulation of transcription, DNA-templated Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of inflammatory response Source: Ensembl
Response to bacterium Source: Ensembl
White fat cell differentiation Source: Ensembl

Cellular Location

Nucleus; Cytoplasm. Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.

Guo, D., Lin, C., Lu, Y., Guan, H., Qi, W., Zhang, H., ... & Cai, D. (2022). FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis. Bone Research, 10(1), 1-15.

Floresta, G., Patamia, V., Zagni, C., & Rescifina, A. (2022). Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022. European Journal of Medicinal Chemistry, 114604.

Prentice, K. J., Saksi, J., Robertson, L. T., Lee, G. Y., Inouye, K. E., Eguchi, K., ... & Hotamisligil, G. S. (2021). A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature, 600(7890), 720-726.

Tian, W., Zhang, W., Zhang, Y., Zhu, T., Hua, Y., Li, H., ... & Xia, M. (2020). FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport. Cancer cell international, 20(1), 1-13.

Zeng, J., Sauter, E. R., & Li, B. (2020). FABP4: a new player in obesity-associated breast cancer. Trends in molecular medicine, 26(5), 437-440.

Mukherjee, A., Chiang, C. Y., Daifotis, H. A., Nieman, K. M., Fahrmann, J. F., Lastra, R. R., ... & Lengyel, E. (2020). Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance. Cancer research, 80(8), 1748-1761.

Prentice, K. J., Saksi, J., & Hotamisligil, G. S. (2019). Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses. Journal of Lipid Research, 60(4), 734-740.

Zhang, Y., Zhao, X., Deng, L., Li, X., Wang, G., Li, Y., & Chen, M. (2019). High expression of FABP4 and FABP6 in patients with colorectal cancer. World Journal of Surgical Oncology, 17(1), 1-13.

Tirosh, A., Calay, E. S., Tuncman, G., Claiborn, K. C., Inouye, K. E., Eguchi, K., ... & Hotamisligil, G. S. (2019). The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Science translational medicine, 11(489), eaav0120.

Gharpure, K. M., Pradeep, S., Sans, M., Rupaimoole, R., Ivan, C., Wu, S. Y., ... & Sood, A. K. (2018). FABP4 as a key determinant of metastatic potential of ovarian cancer. Nature communications, 9(1), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant FABP4 (29 Ala/Thr) protein, His Tag (CAT#: V2LY-0526-LY3981)

FABP4 Matched Antibody Pair (404) (CAT#: APMAB-404LY)

FABP4 Matched Antibody Pair (405) (CAT#: APMAB-405LY)

Antibody Pairs

FABP4 Matched Antibody Pair (404) (CAT#: APMAB-404LY)

FABP4 Matched Antibody Pair (405) (CAT#: APMAB-405LY)

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Mouse Anti-FABP4 Recombinant Antibody (4G1) (CAT#: CBMAB-A2802-LY)

FABP4 Matched Antibody Pair (404) (CAT#: APMAB-404LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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