Mouse Recombinant FGF21 protein, His Tag (V2LY-0526-LY8314)

Name: Mouse Recombinant FGF21 protein, His Tag
SKU: V2LY-0526-LY8314
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant FGF21 protein, His Tag consist of Amino Acid: 1-210 and predicts a molecular mass of 21.3 kDa.

Molecule Mass

21.3 kDa

Sequence

Amino Acid: 1-210

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, TCEP, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 21

Research Area

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to drug Source: Ensembl
Cellular response to glucagon stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: Ensembl
Endothelial cell apoptotic process Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Negative regulation of endothelial cell apoptotic process Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of triglyceride catabolic process Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Response to activity Source: Ensembl
Response to methionine Source: Ensembl
Response to nutrient levels Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

Sommakia, S., Almaw, N. H., Lee, S. H., Ramadurai, D. K., Taleb, I., Kyriakopoulos, C. P., ... & Chaudhuri, D. (2022). FGF21 (Fibroblast Growth Factor 21) defines a potential cardiohepatic signaling circuit in end-stage heart failure. Circulation: Heart Failure, 15(3), e008910.

Lu, H., Jia, C., Wu, D., Jin, H., Lin, Z., Pan, J., ... & Wang, W. (2021). Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway. Cell death & disease, 12(10), 1-13.

Janzi, S., González-Padilla, E., Najafi, K., Ramne, S., Ahlqvist, E., Borné, Y., & Sonestedt, E. (2021). Single Nucleotide Polymorphisms in Close Proximity to the Fibroblast Growth Factor 21 (FGF21) Gene Found to Be Associated with Sugar Intake in a Swedish Population. Nutrients, 13(11), 3954.

Wu, L., Qian, L., Zhang, L., Zhang, J., Zhou, J., Li, Y., ... & Jia, W. (2020). Fibroblast growth factor 21 is related to atherosclerosis independent of nonalcoholic fatty liver disease and predicts atherosclerotic cardiovascular events. Journal of the American Heart Association, 9(11), e015226.

Forsström, S., Jackson, C. B., Carroll, C. J., Kuronen, M., Pirinen, E., Pradhan, S., ... & Suomalainen, A. (2019). Fibroblast growth factor 21 drives dynamics of local and systemic stress responses in mitochondrial myopathy with mtDNA deletions. Cell metabolism, 30(6), 1040-1054.

Tucker, B., Li, H., Long, X., Rye, K. A., & Ong, K. L. (2019). Fibroblast growth factor 21 in non-alcoholic fatty liver disease. Metabolism, 101, 153994.

Martínez-Garza, Ú., Torres-Oteros, D., Yarritu-Gallego, A., Marrero, P. F., Haro, D., & Relat, J. (2019). Fibroblast growth factor 21 and the adaptive response to nutritional challenges. International journal of molecular sciences, 20(19), 4692.

Su, X., Kong, Y., & Peng, D. (2019). Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease. Clinica Chimica Acta, 498, 30-37.

Shi, Y., Wang, S., Peng, H., Lv, Y., Li, W., Cheng, S., & Liu, J. (2019). Fibroblast growth factor 21 attenuates vascular calcification by alleviating endoplasmic reticulum stress mediated apoptosis in rats. International journal of biological sciences, 15(1), 138.

Gao, R. Y., Hsu, B. G., Wu, D. A., Hou, J. S., & Chen, M. C. (2019). Serum fibroblast growth factor 21 levels are positively associated with metabolic syndrome in patients with type 2 diabetes. International journal of endocrinology, 2019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Hamster Recombinant FGF21 protein, His Tag (CAT#: V2LY-0526-LY1810)

Human Recombinant FGF21 protein (CAT#: V2LY-0526-LY4058)

Human Recombinant FGF21 protein, His Tag (CAT#: V2LY-0526-LY4059)

Cynomolgus Recombinant FGF21 protein, His Tag (CAT#: V2LY-0526-LY1515)

Rat Recombinant FGF21 protein, His Tag (CAT#: V2LY-0526-LY9378)

FGF21 Matched Antibody Pair (432) (CAT#: APMAB-432LY)

FGF21 Matched Antibody Pair (433) (CAT#: APMAB-433LY)

FGF21 Matched Antibody Pair (434) (CAT#: APMAB-434LY)

FGF21 Matched Antibody Pair (435) (CAT#: APMAB-435LY)

FGF21 Matched Antibody Pair (436) (CAT#: APMAB-436LY)

Antibody Pairs

FGF21 Matched Antibody Pair (432) (CAT#: APMAB-432LY)

FGF21 Matched Antibody Pair (433) (CAT#: APMAB-433LY)

FGF21 Matched Antibody Pair (434) (CAT#: APMAB-434LY)

FGF21 Matched Antibody Pair (435) (CAT#: APMAB-435LY)

FGF21 Matched Antibody Pair (436) (CAT#: APMAB-436LY)

FGF21 Matched Antibody Pair (437) (CAT#: APMAB-437LY)

Related Products

FGF21 Matched Antibody Pair (432) (CAT#: APMAB-432LY)

Rabbit Anti-FGF21 Recombinant Antibody (CBXF-1872) (CAT#: CBMAB-F3406-CQ)

Cynomolgus Recombinant FGF21 protein, His Tag (CAT#: V2LY-0526-LY1515)

FGF21 Matched Antibody Pair (436) (CAT#: APMAB-436LY)

Rat Recombinant FGF21 protein, His Tag (CAT#: V2LY-0526-LY9378)

Human Anti-FGF21 Recombinant Antibody (CBXF-0574) (CAT#: CBMAB-F1446-CQ)

Mouse Anti-FGF21 Recombinant Antibody (CBXF-0575) (CAT#: CBMAB-F3169-CQ)

Rat Anti-FGF21 Recombinant Antibody (CBXF-2976) (CAT#: CBMAB-F3682-CQ)

Human Anti-FGF21 Recombinant Antibody (CBXF-2974) (CAT#: CBMAB-F3680-CQ)

FGF21 Matched Antibody Pair (437) (CAT#: APMAB-437LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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