FGF21

Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
Full Name
Fibroblast Growth Factor 21
Research Area
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to drug Source: Ensembl
Cellular response to glucagon stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: Ensembl
Endothelial cell apoptotic process Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Negative regulation of endothelial cell apoptotic process Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of triglyceride catabolic process Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Response to activity Source: Ensembl
Response to methionine Source: Ensembl
Response to nutrient levels Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
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Anti-FGF21 antibodies

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Mouse Anti-FGF21 Recombinant Antibody (CBXF-2975) (CBMAB-F3681-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2975
Application*: WB
Datasheet SDS

Mouse Anti-FGF21 Recombinant Antibody (CBXF-2980) (CBMAB-F3686-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2980
Application*: E
Datasheet SDS

Rat Anti-FGF21 Recombinant Antibody (CBXF-2976) (CBMAB-F3682-CQ)

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Target: FGF21
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBXF-2976
Application*: E
Datasheet SDS

Human Anti-FGF21 Recombinant Antibody (CBXF-2974) (CBMAB-F3680-CQ)

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Target: FGF21
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2974
Application*: E
Datasheet SDS

Mouse Anti-FGF21 Recombinant Antibody (CBXF-2973) (CBMAB-F3679-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2973
Application*: IF
Datasheet SDS

Rabbit Anti-FGF21 Recombinant Antibody (CBXF-1872) (CBMAB-F3406-CQ)

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Target: FGF21
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1872
Application*: E
Datasheet SDS

Mouse Anti-FGF21 Recombinant Antibody (CBXF-0575) (CBMAB-F3169-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0575
Application*: E
Datasheet SDS

Mouse Anti-FGF21 Recombinant Antibody (CBXF-2615) (CBMAB-F3042-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2615
Application*: E
Datasheet SDS

Goat Anti-FGF21 Recombinant Antibody (CBXF-2613) (CBMAB-F3040-CQ)

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Target: FGF21
Host: Goat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2613
Application*: N
Functional Assay
Datasheet SDS

Mouse Anti-FGF21 Recombinant Antibody (CBXF-3601) (CBMAB-F2827-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3601
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FGF21 Recombinant Antibody (CBXF-0571) (CBMAB-F2322-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXF-0571
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FGF21 Recombinant Antibody (CBXF-3548) (CBMAB-F2129-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3548
Application*: WB, IP, E
Datasheet SDS

Human Anti-FGF21 Recombinant Antibody (CBXF-0574) (CBMAB-F1446-CQ)

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Target: FGF21
Host: Human
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0574
Application*: E, N
Functional Assay
Datasheet SDS

Mouse Anti-FGF21 Recombinant Antibody (CBXF-0573) (CBMAB-F1445-CQ)

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Target: FGF21
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0573
Application*: E
Datasheet SDS

Rabbit Anti-FGF21 Recombinant Antibody (CBXF-1259) (CBMAB-F0864-CQ)

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Target: FGF21
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1259
Application*: WB, P, IF
Datasheet SDS

FGF21 Matched Antibody Pair (437) (APMAB-437LY)

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Target: FGF21
Specificity: Human
Datasheet SDS

FGF21 Matched Antibody Pair (436) (APMAB-436LY)

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Target: FGF21
Specificity: Human
Datasheet SDS

FGF21 Matched Antibody Pair (435) (APMAB-435LY)

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Target: FGF21
Specificity: Human
Datasheet SDS

FGF21 Matched Antibody Pair (434) (APMAB-434LY)

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Target: FGF21
Specificity: Human
Datasheet SDS

FGF21 Matched Antibody Pair (433) (APMAB-433LY)

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Target: FGF21
Specificity: Human
Datasheet SDS

FGF21 Matched Antibody Pair (432) (APMAB-432LY)

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Target: FGF21
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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