FGF21
Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
Full Name
Fibroblast Growth Factor 21
Research Area
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to drug Source: Ensembl
Cellular response to glucagon stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: Ensembl
Endothelial cell apoptotic process Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Negative regulation of endothelial cell apoptotic process Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of triglyceride catabolic process Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Response to activity Source: Ensembl
Response to methionine Source: Ensembl
Response to nutrient levels Source: Ensembl
Signal transduction Source: ProtInc
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to drug Source: Ensembl
Cellular response to glucagon stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: Ensembl
Endothelial cell apoptotic process Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Negative regulation of endothelial cell apoptotic process Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of triglyceride catabolic process Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Response to activity Source: Ensembl
Response to methionine Source: Ensembl
Response to nutrient levels Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
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Anti-FGF21 antibodies
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CompareTarget: FGF21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2975
Application*: WB
Target: FGF21
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2980
Application*: E
Target: FGF21
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBXF-2976
Application*: E
Target: FGF21
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2974
Application*: E
Target: FGF21
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2973
Application*: IF
Target: FGF21
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1872
Application*: E
Target: FGF21
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0575
Application*: E
Target: FGF21
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2615
Application*: E
Target: FGF21
Host: Goat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2613
Application*: N
Target: FGF21
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3601
Application*: WB, IP, IF, E
Target: FGF21
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXF-0571
Application*: WB, IP, IF, E
Target: FGF21
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3548
Application*: WB, IP, E
Target: FGF21
Host: Human
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0574
Application*: E, N
Target: FGF21
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0573
Application*: E
Target: FGF21
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1259
Application*: WB, P, IF
Target: FGF21
Sensitivity: 0.0035 ng/mL
Detection Range: 0.007-1.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Fgf21
Sensitivity: 0.0094 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: FGF21
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-208
Tag: His Tag
Target: FGF21
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-210
Tag: His Tag
Target: FGF21
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 29-209
Tag: His Tag
Target: FGF21
Expressed Host: E. coli
Sequence: Amino Acid: 29-209
Tag: His Tag
Target: FGF21
Expressed Host: E. coli
Sequence: Amino Acid: 29-209
Target: FGF21
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-209
Tag: His Tag
Target: FGF21
Specificity: Human
Target: FGF21
Specificity: Human
Target: FGF21
Specificity: Human
Target: FGF21
Specificity: Human
Target: FGF21
Specificity: Human
Target: FGF21
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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