Mouse Anti-FGF21 Recombinant Antibody (CBXF-3548) (CBMAB-F2129-CQ)

Name: Mouse Anti-FGF21 Recombinant Antibody (CBXF-3548)
SKU: CBMAB-F2129-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3548

Application

FC, IHC-P, WB

Immunogen

Recombinant protein fragment corresponding to amino acids 29-209 of human FGF21 expressed in E. coli

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 21

Introduction

Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue.

Entrez Gene ID

26291

UniProt ID

Q9NSA1

Alternative Names

Fibroblast Growth Factor 21; FGF-21;

Research Area

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity.

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Cellular response to drug Source: Ensembl
Cellular response to glucagon stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: Ensembl
Endoplasmic reticulum unfolded protein response Source: Ensembl
Endothelial cell apoptotic process Source: Ensembl
Fibroblast growth factor receptor signaling pathway Source: GO_Central
Negative regulation of endothelial cell apoptotic process Source: Ensembl
Negative regulation of neuron death Source: Ensembl
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of gene expression Source: GO_Central
Positive regulation of glucose import Source: UniProtKB
Positive regulation of low-density lipoprotein receptor activity Source: BHF-UCL
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Source: Ensembl
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of triglyceride catabolic process Source: Ensembl
Regulation of cell migration Source: GO_Central
Regulation of low-density lipoprotein particle clearance Source: BHF-UCL
Response to activity Source: Ensembl
Response to methionine Source: Ensembl
Response to nutrient levels Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

Sommakia, S., Almaw, N. H., Lee, S. H., Ramadurai, D. K., Taleb, I., Kyriakopoulos, C. P., ... & Chaudhuri, D. (2022). FGF21 (Fibroblast Growth Factor 21) defines a potential cardiohepatic signaling circuit in end-stage heart failure. Circulation: Heart Failure, 15(3), e008910.

Lu, H., Jia, C., Wu, D., Jin, H., Lin, Z., Pan, J., ... & Wang, W. (2021). Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway. Cell death & disease, 12(10), 1-13.

Janzi, S., González-Padilla, E., Najafi, K., Ramne, S., Ahlqvist, E., Borné, Y., & Sonestedt, E. (2021). Single Nucleotide Polymorphisms in Close Proximity to the Fibroblast Growth Factor 21 (FGF21) Gene Found to Be Associated with Sugar Intake in a Swedish Population. Nutrients, 13(11), 3954.

Wu, L., Qian, L., Zhang, L., Zhang, J., Zhou, J., Li, Y., ... & Jia, W. (2020). Fibroblast growth factor 21 is related to atherosclerosis independent of nonalcoholic fatty liver disease and predicts atherosclerotic cardiovascular events. Journal of the American Heart Association, 9(11), e015226.

Forsström, S., Jackson, C. B., Carroll, C. J., Kuronen, M., Pirinen, E., Pradhan, S., ... & Suomalainen, A. (2019). Fibroblast growth factor 21 drives dynamics of local and systemic stress responses in mitochondrial myopathy with mtDNA deletions. Cell metabolism, 30(6), 1040-1054.

Tucker, B., Li, H., Long, X., Rye, K. A., & Ong, K. L. (2019). Fibroblast growth factor 21 in non-alcoholic fatty liver disease. Metabolism, 101, 153994.

Martínez-Garza, Ú., Torres-Oteros, D., Yarritu-Gallego, A., Marrero, P. F., Haro, D., & Relat, J. (2019). Fibroblast growth factor 21 and the adaptive response to nutritional challenges. International journal of molecular sciences, 20(19), 4692.

Su, X., Kong, Y., & Peng, D. (2019). Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease. Clinica Chimica Acta, 498, 30-37.

Shi, Y., Wang, S., Peng, H., Lv, Y., Li, W., Cheng, S., & Liu, J. (2019). Fibroblast growth factor 21 attenuates vascular calcification by alleviating endoplasmic reticulum stress mediated apoptosis in rats. International journal of biological sciences, 15(1), 138.

Gao, R. Y., Hsu, B. G., Wu, D. A., Hou, J. S., & Chen, M. C. (2019). Serum fibroblast growth factor 21 levels are positively associated with metabolic syndrome in patients with type 2 diabetes. International journal of endocrinology, 2019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FGF21 Matched Antibody Pair (432) (CAT#: APMAB-432LY)

FGF21 Matched Antibody Pair (433) (CAT#: APMAB-433LY)

FGF21 Matched Antibody Pair (434) (CAT#: APMAB-434LY)

FGF21 Matched Antibody Pair (435) (CAT#: APMAB-435LY)

FGF21 Matched Antibody Pair (436) (CAT#: APMAB-436LY)

FGF21 Matched Antibody Pair (437) (CAT#: APMAB-437LY)

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FGF21 Matched Antibody Pair (436) (CAT#: APMAB-436LY)

FGF21 Matched Antibody Pair (432) (CAT#: APMAB-432LY)

Mouse Anti-FGF21 Recombinant Antibody (CBXF-2974) (CAT#: CBMAB-F3680-CQ)

FGF21 Matched Antibody Pair (433) (CAT#: APMAB-433LY)

Mouse Anti-FGF21 Recombinant Antibody (CBXF-3715) (CAT#: CBMAB-F1039-CQ)

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Mouse Anti-FGF21 Recombinant Antibody (CBXF-0572) (CAT#: CBMAB-F0863-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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