Mouse Recombinant HGF protein, His Tag (V2LY-0526-LY8399)

Name: Mouse Recombinant HGF protein, His Tag
SKU: V2LY-0526-LY8399
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant HGF protein, His Tag consist of Amino Acid: 1-728 and predicts a molecular mass of 80.8 kDa.

Molecule Mass

80.8 kDa

Sequence

Amino Acid: 1-728

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>70% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Hepatocyte Growth Factor

Function

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Biological Process

Animal organ regeneration Source: Ensembl
Cell chemotaxis Source: BHF-UCL
Cell morphogenesis Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: BHF-UCL
Epithelial cell proliferation Source: Ensembl
Epithelial to mesenchymal transition Source: HGNC-UCL
Hepatocyte growth factor receptor signaling pathway Source: BHF-UCL
Liver development Source: Ensembl
Mitotic cell cycle Source: UniProtKB
Myoblast proliferation Source: Ensembl
Negative regulation of apoptotic process Source: GO_Central
Negative regulation of autophagy Source: ParkinsonsUK-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Negative regulation of hydrogen peroxide-mediated programmed cell death Source: BHF-UCL
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of interleukin-6 production Source: Ensembl
Negative regulation of peptidyl-serine phosphorylation Source: Ensembl
Negative regulation of release of cytochrome c from mitochondria Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of DNA biosynthetic process Source: UniProtKB
Positive regulation of interleukin-10 production Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of myelination Source: Ensembl
Positive regulation of neuron projection regeneration Source: Ensembl
Positive regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
Regulation of p38MAPK cascade Source: Ensembl
Regulation of tau-protein kinase activity Source: Ensembl

Cellular Location

Extracellular region; Extracellular space; Membrane; Platelet alpha granule lumen

Involvement in disease

Deafness, autosomal recessive, 39 (DFNB39):
A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Tonomura, H., Nagae, M., Takatori, R., Ishibashi, H., Itsuji, T., & Takahashi, K. (2020). The potential role of hepatocyte growth factor in degenerative disorders of the synovial joint and spine. International journal of molecular sciences, 21(22), 8717.

Lu, Z., Chang, W., Meng, S., Xu, X., Xie, J., Guo, F., ... & Liu, L. (2019). Mesenchymal stem cells induce dendritic cell immune tolerance via paracrine hepatocyte growth factor to alleviate acute lung injury. Stem Cell Research & Therapy, 10, 1-16.

Sakai, K., Passioura, T., Sato, H., Ito, K., Furuhashi, H., Umitsu, M., ... & Matsumoto, K. (2019). Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor. Nature chemical biology, 15(6), 598-606.

Zhang, H., Wang, Y., Bai, M., Wang, J., Zhu, K., Liu, R., ... & Ba, Y. (2018). Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor si RNA. Cancer science, 109(3), 629-641.

Yamane, K., Mazaki, T., Shiozaki, Y., Yoshida, A., Shinohara, K., Nakamura, M., ... & Matsukawa, A. (2018). Collagen-binding hepatocyte growth factor (HGF) alone or with a gelatin-furfurylamine hydrogel enhances functional recovery in mice after spinal cord injury. Scientific reports, 8(1), 917.

Fukushima, T., Uchiyama, S., Tanaka, H., & Kataoka, H. (2018). Hepatocyte growth factor activator: a proteinase linking tissue injury with repair. International Journal of Molecular Sciences, 19(11), 3435.

Ko, K. R., Lee, J., Lee, D., Nho, B., & Kim, S. (2018). Hepatocyte growth factor (HGF) promotes peripheral nerve regeneration by activating repair Schwann cells. Scientific Reports, 8(1), 8316.

Wang, L. S., Wang, H., Zhang, Q. L., Yang, Z. J., Kong, F. X., & Wu, C. T. (2018). Hepatocyte growth factor gene therapy for ischemic diseases. Human gene therapy, 29(4), 413-423.

Miyagi, H., Thomasy, S. M., Russell, P., & Murphy, C. J. (2018). The role of hepatocyte growth factor in corneal wound healing. Experimental eye research, 166, 49-55.

Oliveira, A. G., Araújo, T. G., Carvalho, B. D. M., Rocha, G. Z., Santos, A., & Saad, M. J. (2018). The role of hepatocyte growth factor (HGF) in insulin resistance and diabetes. Frontiers in endocrinology, 9, 503.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant HGF protein (CAT#: V2LY-0526-LY191)

Canine Recombinant HGF protein (CAT#: V2LY-0526-LY1260)

Cynomolgus Recombinant HGF protein (CAT#: V2LY-0526-LY1533)

Mouse Recombinant HGF protein (CAT#: V2LY-0526-LY8398)

Rat Recombinant HGF protein (CAT#: V2LY-0526-LY9422)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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