HGF

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

Hepatocyte Growth Factor

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Animal organ regeneration Source: Ensembl
Cell chemotaxis Source: BHF-UCL
Cell morphogenesis Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: BHF-UCL
Epithelial cell proliferation Source: Ensembl
Epithelial to mesenchymal transition Source: HGNC-UCL
Hepatocyte growth factor receptor signaling pathway Source: BHF-UCL
Liver development Source: Ensembl
Mitotic cell cycle Source: UniProtKB
Myoblast proliferation Source: Ensembl
Negative regulation of apoptotic process Source: GO_Central
Negative regulation of autophagy Source: ParkinsonsUK-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Negative regulation of hydrogen peroxide-mediated programmed cell death Source: BHF-UCL
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of interleukin-6 production Source: Ensembl
Negative regulation of peptidyl-serine phosphorylation Source: Ensembl
Negative regulation of release of cytochrome c from mitochondria Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of DNA biosynthetic process Source: UniProtKB
Positive regulation of interleukin-10 production Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of myelination Source: Ensembl
Positive regulation of neuron projection regeneration Source: Ensembl
Positive regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
Regulation of p38MAPK cascade Source: Ensembl
Regulation of tau-protein kinase activity Source: Ensembl

Extracellular region; Extracellular space; Membrane; Platelet alpha granule lumen

Deafness, autosomal recessive, 39 (DFNB39):
A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.