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Mouse Anti-HGF (AA 200-494) Recombinant Antibody (CBFYH-1013) (CBMAB-H1960-FY)

This product is mouse antibody that recognizes HGF. The antibody CBFYH-1013 can be used for immunoassay techniques such as: WB, IHC.
See all HGF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1013
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 200-494 of human HGF produced in E.coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 200-494

Target

Full Name
Hepatocyte Growth Factor
Introduction
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.
Entrez Gene ID
UniProt ID
Alternative Names
Hepatocyte Growth Factor; Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor); Fibroblast-Derived Tumor Cytotoxic Factor; Lung Fibroblast-Derived Mitogen; Hepatopoietin-A; Scatter Factor; HPTA; SF
Function
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Biological Process
Animal organ regeneration Source: Ensembl
Cell chemotaxis Source: BHF-UCL
Cell morphogenesis Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: BHF-UCL
Epithelial cell proliferation Source: Ensembl
Epithelial to mesenchymal transition Source: HGNC-UCL
Hepatocyte growth factor receptor signaling pathway Source: BHF-UCL
Liver development Source: Ensembl
Mitotic cell cycle Source: UniProtKB
Myoblast proliferation Source: Ensembl
Negative regulation of apoptotic process Source: GO_Central
Negative regulation of autophagy Source: ParkinsonsUK-UCL
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Negative regulation of hydrogen peroxide-mediated programmed cell death Source: BHF-UCL
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of interleukin-6 production Source: Ensembl
Negative regulation of peptidyl-serine phosphorylation Source: Ensembl
Negative regulation of release of cytochrome c from mitochondria Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of DNA biosynthetic process Source: UniProtKB
Positive regulation of interleukin-10 production Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of myelination Source: Ensembl
Positive regulation of neuron projection regeneration Source: Ensembl
Positive regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Source: MGI
Regulation of p38MAPK cascade Source: Ensembl
Regulation of tau-protein kinase activity Source: Ensembl
Cellular Location
Extracellular region; Extracellular space; Membrane; Platelet alpha granule lumen
Involvement in disease
Deafness, autosomal recessive, 39 (DFNB39):
A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Tonomura, H., Nagae, M., Takatori, R., Ishibashi, H., Itsuji, T., & Takahashi, K. (2020). The potential role of hepatocyte growth factor in degenerative disorders of the synovial joint and spine. International journal of molecular sciences, 21(22), 8717.

Lu, Z., Chang, W., Meng, S., Xu, X., Xie, J., Guo, F., ... & Liu, L. (2019). Mesenchymal stem cells induce dendritic cell immune tolerance via paracrine hepatocyte growth factor to alleviate acute lung injury. Stem Cell Research & Therapy, 10, 1-16.

Sakai, K., Passioura, T., Sato, H., Ito, K., Furuhashi, H., Umitsu, M., ... & Matsumoto, K. (2019). Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor. Nature chemical biology, 15(6), 598-606.

Zhang, H., Wang, Y., Bai, M., Wang, J., Zhu, K., Liu, R., ... & Ba, Y. (2018). Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor si RNA. Cancer science, 109(3), 629-641.

Yamane, K., Mazaki, T., Shiozaki, Y., Yoshida, A., Shinohara, K., Nakamura, M., ... & Matsukawa, A. (2018). Collagen-binding hepatocyte growth factor (HGF) alone or with a gelatin-furfurylamine hydrogel enhances functional recovery in mice after spinal cord injury. Scientific reports, 8(1), 917.

Fukushima, T., Uchiyama, S., Tanaka, H., & Kataoka, H. (2018). Hepatocyte growth factor activator: a proteinase linking tissue injury with repair. International Journal of Molecular Sciences, 19(11), 3435.

Ko, K. R., Lee, J., Lee, D., Nho, B., & Kim, S. (2018). Hepatocyte growth factor (HGF) promotes peripheral nerve regeneration by activating repair Schwann cells. Scientific Reports, 8(1), 8316.

Wang, L. S., Wang, H., Zhang, Q. L., Yang, Z. J., Kong, F. X., & Wu, C. T. (2018). Hepatocyte growth factor gene therapy for ischemic diseases. Human gene therapy, 29(4), 413-423.

Miyagi, H., Thomasy, S. M., Russell, P., & Murphy, C. J. (2018). The role of hepatocyte growth factor in corneal wound healing. Experimental eye research, 166, 49-55.

Oliveira, A. G., Araújo, T. G., Carvalho, B. D. M., Rocha, G. Z., Santos, A., & Saad, M. J. (2018). The role of hepatocyte growth factor (HGF) in insulin resistance and diabetes. Frontiers in endocrinology, 9, 503.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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