Mouse Recombinant PLAT protein, hFc Tag (V2LY-0526-LY9004)

Name: Mouse Recombinant PLAT protein, hFc Tag
SKU: V2LY-0526-LY9004
Rating: 5 (1 reviews)

See all PLAT antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

hFc Tag

Protein Construction

This product is Mouse Recombinant PLAT protein, hFc Tag consist of Amino Acid: 309-559 and predicts a molecular mass of 56.4 kDa.

Molecule Mass

56.4 kDa

Sequence

Amino Acid: 309-559

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>80% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Plasminogen Activator, Tissue Type

Function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).

Biological Process

Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to dexamethasone stimulusIEA:Ensembl
Cellular response to follicle-stimulating hormone stimulusIEA:Ensembl
Cellular response to luteinizing hormone stimulusIEA:Ensembl
FibrinolysisTAS:Reactome
Negative regulation of fibrinolysis1 PublicationIC:ComplexPortal
Negative regulation of plasminogen activation1 PublicationIC:ComplexPortal
Negative regulation of proteolysisManual Assertion Based On ExperimentIDA:BHF-UCL
Plasminogen activationManual Assertion Based On ExperimentIDA:UniProtKB
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of ovulationIEA:Ensembl
Prevention of polyspermyISS:UniProtKB
Protein modification processManual Assertion Based On ExperimentTAS:ProtInc
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of synaptic plasticityIEA:Ensembl
Response to cAMPIEA:Ensembl
Response to fatty acidIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Smooth muscle cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Synaptic transmission, glutamatergicIEA:Ensembl
Trans-synaptic signaling by BDNF, modulating synaptic transmissionIEA:Ensembl

Cellular Location

Secreted, extracellular space

Involvement in disease

Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.

PTM

The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.
Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.
N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.
Characterization of O-linked glycan was studied in Bowes melanoma cell line.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Recombinant PLAT protein, hFc Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PLAT protein (CAT#: V2LY-0526-LY7323)

Human Recombinant PLAT protein, hFc Tag (CAT#: V2LY-0526-LY7324)

Human Recombinant PLAT protein, hFc Tag-1 (CAT#: V2LY-0526-LY7325)

Human Recombinant PLAT protein-1 (CAT#: V2LY-0526-LY7326)

Related Products

Human Recombinant PLAT protein, hFc Tag (CAT#: V2LY-0526-LY7324)

Mouse Anti-PLAT Recombinant Antibody (T-1) (CAT#: CBMAB-T0594-YJ)

Rabbit Anti-PLAT Recombinant Antibody (
32B1) (CAT#: V2LY-0725-LY1348)

Mouse Anti-PLAT Recombinant Antibody (3H3) (CAT#: CBMAB-P2023-YC)

Human Recombinant PLAT protein-1 (CAT#: V2LY-0526-LY7326)

Mouse Anti-PLAT Recombinant Antibody (2 VPA) (CAT#: CBMAB-P2022-YC)

Mouse Anti-PLAT Recombinant Antibody (CBYJT-1555) (CAT#: CBMAB-T0591-YJ)

Mouse Anti-PLAT Recombinant Antibody (CBYJT-1554) (CAT#: CBMAB-T0590-YJ)

Mouse Anti-Plat Recombinant Antibody (CBYJT-1560) (CAT#: CBMAB-T0597-YJ)

Mouse Anti-PLAT Recombinant Antibody (CBYC-P421) (CAT#: CBMAB-P2025-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry