Mouse Recombinant TFRC protein, ECD, His Tag (V2LY-0526-LY9012)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).
A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738).
When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738).
When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738).
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
Biological Process agingSource:Ensembl
Biological Process cellular iron ion homeostasisSource:GO_Central1 Publication
Biological Process cellular response to leukemia inhibitory factorSource:Ensembl
Biological Process cellular response to xenobiotic stimulusSource:MGI1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process iron ion transportSource:UniProtKB1 Publication
Biological Process negative regulation of apoptotic processSource:ARUK-UCL1 Publication
Biological Process negative regulation of mitochondrial fusionSource:UniProtKB1 Publication
Biological Process osteoclast differentiationSource:Ensembl
Biological Process positive regulation of B cell proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of bone resorptionSource:Ensembl
Biological Process positive regulation of gene expressionSource:ARUK-UCL1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:ARUK-UCL1 Publication
Biological Process positive regulation of isotype switchingSource:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activitySource:ARUK-UCL1 Publication
Biological Process positive regulation of peptidyl-serine phosphorylationSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein localization to nucleusSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein phosphorylationSource:ARUK-UCL1 Publication
Biological Process positive regulation of protein-containing complex assemblySource:ARUK-UCL1 Publication
Biological Process positive regulation of T cell proliferationSource:UniProtKB1 Publication
Biological Process receptor internalizationSource:UniProtKB1 Publication
Biological Process response to copper ionSource:Ensembl
Biological Process response to hypoxiaSource:Ensembl
Biological Process response to iron ionSource:Ensembl
Biological Process response to manganese ionSource:Ensembl
Biological Process response to nutrientSource:Ensembl
Biological Process response to retinoic acidSource:Ensembl
Biological Process transferrin transportSource:UniProtKB1 Publication
Biological Process transport across blood-brain barrierSource:ARUK-UCL2 Publications
Melanosome
Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Transferrin receptor protein 1, serum form
Secreted
An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia.
Helical: 68-88
Extracellular: 89-760
Stearoylation does not affect iron uptake (PubMed:26214738).
N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Cynomolgus, Rhesus Recombinant CD71 protein, His Tag (CAT#: V2LY-0526-LY1748)Cynomolgus, Rhesus Recombinant CD71 protein, His Tag-1 (CAT#: V2LY-0526-LY1749)
Human Recombinant TFRC protein, ECD, Biotin Conjugated, AVI & His Tag (CAT#: V2LY-0526-LY7354)
Human Recombinant TFRC protein, ECD, His Tag (CAT#: V2LY-0526-LY7355)
Human Recombinant TFRC protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY7356)
Human Recombinant TFRC protein, hFc Tag (CAT#: V2LY-0526-LY7357)
Human Recombinant TFRC protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY7358)
Mouse Recombinant TFRC protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY9013)
Mouse Recombinant TFRC protein, His Tag (CAT#: V2LY-0526-LY9014)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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