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NOVA1 Matched Antibody Pair (810) (APMAB-810LY)

This antibody pair set can be used for detecting and quantifying protein level of human NOVA1.
See all NOVA1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NOVA1 polyclonal antibody, 100 ug
Detection Antibody
Anti-NOVA1 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Alternative Names
NOVA Alternative Splicing Regulator 1; Neuro-Oncological Ventral Antigen 1; Ventral Neuron-Specific Protein 1; Onconeural Ventral Antigen 1; Paraneoplastic Ri Antigen; RNA-Binding Protein Nova-1; Nova-1;
Entrez Gene ID
4857
UniProt ID
P51513

Pedraza-Arevalo, S., Alors-Pérez, E., Blázquez-Encinas, R., Herrera-Martínez, A. D., Jiménez-Vacas, J. M., Fuentes-Fayos, A. C., ... & Castaño, J. P. (2023). Spliceosomic dysregulation unveils NOVA1 as a candidate actionable therapeutic target in pancreatic neuroendocrine tumors. Translational Research, 251, 63-73.

Tajima, Y., Ito, K., Yuan, Y., Frank, M. O., Saito, Y., & Darnell, R. B. (2023). NOVA1 acts on Impact to regulate hypothalamic function and translation in inhibitory neurons. Cell Reports, 42(2).

Krach, F., Wheeler, E. C., Regensburger, M., Boerstler, T., Wend, H., Vu, A. Q., ... & Winner, B. (2022). Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis. Acta Neuropathologica, 144(3), 413-435.

Brahma, M. K., Xiao, P., Popa, M., Negueruela, J., Vandenbempt, V., Demine, S., ... & Gurzov, E. N. (2022). Nova1 or Bim Deficiency in Pancreatic β-Cells Does Not Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced Obesity in Mice. Nutrients, 14(18), 3866.

Qu, L., Tian, Y., Wang, F., & Li, Z. (2022). NOVA1 promotes NSCLC proliferation and invasion by activating Wnt/β-catenin signaling. BMC cancer, 22(1), 1-13.

Trujillo, C. A., Rice, E. S., Schaefer, N. K., Chaim, I. A., Wheeler, E. C., Madrigal, A. A., ... & Muotri, A. R. (2021). Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment. Science, 371(6530), eaax2537.

Maricic, T., Helmbrecht, N., Riesenberg, S., Macak, D., Kanis, P., Lackner, M., ... & Pääbo, S. (2021). Comment on “Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment”. Science, 374(6565), eabi6060.

Zhang, T., Chen, S., Peng, Y., Wang, C., Cheng, X., Zhao, R., & Liu, K. (2021). NOVA1-mediated SORBS2 isoform promotes colorectal cancer migration by activating the Notch pathway. Frontiers in Cell and Developmental Biology, 9, 673873.

Jin, L., Li, H., Wang, J., Lin, D., Yin, K., Lin, L., ... & Teng, L. (2019). MicroRNA‐193a‐5p exerts a tumor suppressor role in glioblastoma via modulating NOVA1. Journal of cellular biochemistry, 120(4), 6188-6197.

Sayed, M. E., Yuan, L., Robin, J. D., Tedone, E., Batten, K., Dahlson, N., ... & Ludlow, A. T. (2019). NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells. Oncogene, 38(16), 2937-2952.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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