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Rabbit Anti-AK4 Recombinant Antibody (V2-180404) (CBMAB-A1876-YC)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
V2-180404
Antibody Isotype
IgG
Application
ELISA, IP

Basic Information

Immunogen
Recombinant Human AK4/AK3L1 protein
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000
IP1-4 μl/mg of lysate

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 2-223

Target

Full Name
Adenylate Kinase 4
Introduction
AK4 is a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phos
Entrez Gene ID
205
UniProt ID
P27144
Alternative Names
Adenylate Kinase 4; Adenylate Kinase 3-Like 1; AK3L1; AK 4; AK3; GTP:AMP Phosphotransferase AK4, Mitochondrial; Adenylate Kinase Isoenzyme 4, Mitochondrial; Nucleoside-Triphosphate-Adenylate Kinase; Adenylate Kinase 4, Mitochondrial; Mitochondrial Adenyla
Function
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (PubMed:19073142, PubMed:19766732, PubMed:23416111, PubMed:24767988). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (PubMed:19073142, PubMed:19766732, PubMed:23416111). Also displays broad nucleoside diphosphate kinase activity (PubMed:19073142, PubMed:19766732, PubMed:23416111). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (PubMed:24767988, PubMed:26980435). Plays a protective role in the cellular response to oxidative stress (PubMed:19130895, PubMed:23474458, PubMed:26980435).
Biological Process
ADP biosynthetic process Source: UniProtKB-UniRule
AMP metabolic process Source: BHF-UCL
ATP metabolic process Source: BHF-UCL
Brain development Source: Ensembl
Cellular response to hypoxia Source: UniProtKB
GTP metabolic process Source: BHF-UCL
Liver development Source: Ensembl
Nucleobase-containing small molecule interconversion Source: Reactome
Nucleoside diphosphate phosphorylation Source: UniProtKB
Nucleoside triphosphate biosynthetic process Source: UniProtKB
Regulation of ATP biosynthetic process Source: UniProtKB
Regulation of oxidative phosphorylation Source: UniProtKB
Response to drug Source: Ensembl
Cellular Location
Mitochondrion matrix
More Infomation

Chin, W. Y., He, C. Y., Chow, T. W., Yu, Q. Y., Lai, L. C., & Miaw, S. C. (2021). Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages. Frontiers in Immunology, 12.

Liu, X., Gonzalez, G., Dai, X., Miao, W., Yuan, J., Huang, M., ... & Wang, Y. (2020). Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m6A-Based Epitranscriptomic Mechanism. Molecular Therapy, 28(12), 2593-2604.

Jan, Y. H., Lai, T. C., Yang, C. J., Lin, Y. F., Huang, M. S., & Hsiao, M. (2019). Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis. Journal of hematology & oncology, 12(1), 1-14.

Xin, F., Yao, D. W., Fan, L., Liu, J. H., & Liu, X. D. (2019). Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion. Clinical and experimental medicine, 19(4), 525-534.

Jan, Y. H., Lai, T. C., Yang, C. J., Huang, M. S., & Hsiao, M. (2019). A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma. Scientific reports, 9(1), 1-11.

Wujak, M., Wilke, T., Weiss, A., Brosien, M., Wu, C. Y., Schermuly, R. T., ... & Weissmann, N. (2019). Role of adenylate kinase 4 as a new metabolic regulator of pulmonary artery smooth muscle cells under hypoxia.

Wujak, M., Brosien, M., Wu, C. Y., Schermuly, R. T., Ghofrani, H. A., Seeger, W., ... & Weissmann, N. (2019). Emerging Role of Adenylate Kinase 4 as a Metabolic Player Regulating Cellular Hypoxic Responses in Pulmonary Cells. In C60. VASCULAR BIOLOGY IN LUNG DISEASE (pp. A5287-A5287). American Thoracic Society.

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For research use only. Not intended for any clinical use.

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