Rabbit Anti-H1-4 (Phospho-Thr17) Recombinant Antibody (CBFYH-1153) (V2LY-0226-LY2434)

Name: Rabbit Anti-H1-4 (Phospho-Thr17) Recombinant Antibody (CBFYH-1153)
SKU: V2LY-0226-LY2434
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBFYH-1153

Application

WB, IF, IHC

Immunogen

Human H1-4.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, BSA, glycerol

Preservative

Sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

H1.4 linker histone, cluster member

Entrez Gene ID

3008

UniProt ID

P10412

Alternative Names

H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5

Function

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Biological Process

Chromosome condensation
Negative regulation of DNA recombinationSource:GO_Central
Negative regulation of transcription by RNA polymerase IISource:Ensembl
Nucleosome assembly

Cellular Location

Nucleus
Chromosome
Note: Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus.

Involvement in disease

Rahman syndrome (RMNS):
An autosomal dominant syndrome characterized by intellectual disability and overgrowth manifesting as increased birth length, height, weight, and/or head circumference.

PTM

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.
Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
ADP-ribosylated on Ser-150 in response to DNA damage.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-H1-4 (Phospho-Thr17) Recombinant Antibody (CBFYH-1155) (CAT#: V2LY-0226-LY2445)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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