Rat C1qb ELISA Kit (V2LY-0626-LY2150)

Name: Rat C1qb ELISA Kit
SKU: V2LY-0626-LY2150
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

3.15 ng/mL

Detection Range

0.6-180 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Rat

Assay Type

Sandwich

Reactivity

Rat

Assay Time

1.5 h

Molecule Mass

26.6 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

complement C1q B chain

Function

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Biological Process

Complement activation Source: Reactome
Complement activation, classical pathway Source: Reactome
Innate immune response Source: UniProtKB-KW
Regulation of complement activation Source: Reactome
Synapse pruning Source: ARUK-UCL

Cellular Location

Secreted

Involvement in disease

Complement component C1q deficiency (C1QD): A disorder caused by impaired activation of the complement classical pathway. It generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

PTM

Hydroxylated on lysine and proline residues. Hydroxylated lysine residues can be glycosylated. Human C1Q contains up to 68.3 hydroxylysine-galactosylglucose residues and up to 2.5 hydroxylysine-galactose per molecule. Total percentage hydroxylysine residues glycosylated is 86.4%.

Chen, L. H., Liu, J. F., Lu, Y., He, X. Y., Zhang, C., & Zhou, H. H. (2021). Complement C1q (C1qA, C1qB, and C1qC) May Be a Potential Prognostic Factor and an Index of Tumor Microenvironment Remodeling in Osteosarcoma. Frontiers in oncology, 11, 1643.

Mamoor, S. (2021). Chain A, B, and C of the complement component C1q are differentially expressed in human epithelial ovarian cancer.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

C1QB Matched Antibody Pair (155) (CAT#: APMAB-155LY)

Human Recombinant C1QB protein, His Tag (CAT#: V2LY-0526-LY2454)

Antibody Pairs

C1QB Matched Antibody Pair (155) (CAT#: APMAB-155LY)

Related Products

C1QB Matched Antibody Pair (155) (CAT#: APMAB-155LY)

Rabbit Anti-C1QB Recombinant Antibody (18C15) (CAT#: CBMAB-1237-CN)

Mouse Anti-C1QB Recombinant Antibody (1236) (CAT#: CBMAB-1236-CN)

Rabbit Anti-C1QB Recombinant Antibody (EG434) (CAT#: CBMAB-EN493-LY)

Human Recombinant C1QB protein, His Tag (CAT#: V2LY-0526-LY2454)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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