Human AIMP1 ELISA Kit (V2LY-0626-LY4341)

Name: Human AIMP1 ELISA Kit
SKU: V2LY-0626-LY4341
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0074 ng/mL

Detection Range

0.015-3 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

34.4 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 1

Function

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550).

Biological Process

Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Cell-cell signaling Source: HGNC-UCL
Defense response to virus Source: Ensembl
Inflammatory response Source: UniProtKB-KW
Leukocyte migration Source: HGNC-UCL
Negative regulation of endothelial cell proliferation Source: HGNC-UCL
Positive regulation of glucagon secretion Source: UniProtKB
tRNA aminoacylation for protein translation Source: Reactome

Cellular Location

Golgi apparatus; Secreted; Nucleus; Endoplasmic reticulum; Cytosol. Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Secreted in response to hypoxia (PubMed:10850427). Also secreted in response to both apoptotic and necrotic cell death.

Involvement in disease

Leukodystrophy, hypomyelinating, 3 (HLD3): A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system.

PTM

Cleaved by caspase-7 in response to apoptosis to produce EMAP-II.

Lee, D. D., Hochstetler, A., Sah, E., Xu, H., Lowe, C. W., Santiaguel, S., ... & Schwarz, M. A. (2020). Influence of aminoacyl-tRNA synthetase complex-interacting multifunctional protein 1 on epithelial differentiation and organization during lung development. American Journal of Physiology-Lung Cellular and Molecular Physiology, 319(2), L369-L379.

Mun, C. H., Kim, J. O., Ahn, S. S., Yoon, T., Kim, S. J., Ko, E., ... & Park, S. G. (2019). Atializumab, a humanized anti-aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) antibody significantly improves nephritis in (NZB/NZW) F1 mice. Biomaterials, 220, 119408.

Ahn, S. S., Kim, J. O., Yoon, T., Song, J. J., Park, Y. B., Lee, S. W., & Park, S. G. (2019). Serum aminoacyl-tRNA synthetase-interacting multifunctional protein-1 can predict severe antineutrophil cytoplasmic antibody-associated vasculitis: a pilot monocentric study. BioMed research international, 2019.

Accogli, A., Russell, L., Sébire, G., Rivière, J. B., St-Onge, J., Addour-Boudrahem, N., ... & Srour, M. (2019). Pathogenic variants in AIMP1 cause pontocerebellar hypoplasia. neurogenetics, 20(2), 103-108.

Khan, A., Bennett, J., Scantlebury, M. H., Wei, X. C., & Kerr, M. (2019). AIMP1 mutation long-term follow-up, with decreased brain N-acetylaspartic acid and secondary mitochondrial abnormalities. Child neurology open, 6, 2329048X19829520.

Kim, M. S., Song, J. H., Cohen, E. P., Cho, D., & Kim, T. S. (2017). Aminoacyl tRNA synthetase–interacting multifunctional protein 1 activates NK cells via macrophages in vitro and in vivo. The Journal of Immunology, 198(10), 4140-4147.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant AIMP1 protein, His Tag (CAT#: V2LY-0526-LY3831)

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Isotype control

For research use only. Not intended for any clinical use.

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