Rat Map2 ELISA Kit (V2LY-0626-LY1939)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.022 ng/mL
Detection Range
0.05-10 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
202.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Microtubule Associated Protein 2
Alternative Names
Microtubule Associated Protein 2; MAP-2; Microtubule-Associated Protein 2; MAP2A; MAP2B; MAP2C;
Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Biological Process
Central nervous system neuron developmentManual Assertion Based On ExperimentIEP:DFLAT
Dendrite developmentManual Assertion Based On ExperimentTAS:ARUK-UCL
Dendrite morphogenesisManual Assertion Based On ExperimentIEP:DFLAT
Microtubule bundle formationIEA:InterPro
Microtubule cytoskeleton organizationISS:ARUK-UCL
Negative regulation of axon extensionISS:ARUK-UCL
Negative regulation of microtubule bindingISS:ARUK-UCL
Negative regulation of microtubule polymerizationISS:ARUK-UCL
Neuron projection developmentManual Assertion Based On ExperimentIEP:DFLAT
Positive regulation of anterograde dense core granule transportISS:ARUK-UCL
Positive regulation of anterograde synaptic vesicle transportISS:ARUK-UCL
Regulation of microtubule polymerizationManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of organelle transport along microtubuleISS:ARUK-UCL
Regulation of protein localizationISS:ARUK-UCL
Cellular Location
Cytoplasm, cytoskeleton
Cell projection, dendrite
PTM
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).
Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).

Nishida, K., Matsumura, K., Tamura, M., Nakamichi, T., Shimamori, K., Kuragano, M., ... & Tokuraku, K. (2023). Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules’ physical properties and neurite morphology. Scientific Reports, 13(1), 8870.

Yang, L., Xu, X., & Zheng, J. (2020). Microtubule-associated protein 2 knockdown sensitizes glioma cells to vincristine treatment. Neuroreport, 31(3), 197-204.

Avdoshina, V., Mahoney, M., Gilmore, S. F., Wenzel, E. D., Anderson, A., Letendre, S. L., ... & Mocchetti, I. (2020). HIV influences microtubule associated protein-2: potential marker of HIV-associated neurocognitive disorders. AIDS (London, England), 34(7), 979.

Kim, Y., Jang, Y. N., Kim, J. Y., Kim, N., Noh, S., Kim, H., ... & Lee, K. J. (2020). Microtubule‐associated protein 2 mediates induction of long‐term potentiation in hippocampal neurons. The FASEB Journal, 34(5), 6965-6983.

Le Large, T. Y. S., El Hassouni, B., Funel, N., Kok, B., Piersma, S. R., Pham, T. V., ... & Giovannetti, E. (2019). Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment. Therapeutic advances in medical oncology, 11, 1758835919841233.

McKinney, B. C., MacDonald, M. L., Newman, J. T., Shelton, M. A., DeGiosio, R. A., Kelly, R. M., ... & Sweet, R. A. (2019). Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia. Neuropsychopharmacology, 44(6), 1055-1061.

Bora, G., Sucularli, C., Hensel, N., Claus, P., & Yurter, H. (2019). Investigations of microtubule-associated protein 2 gene expression in spinal muscular atrophy. Journal of Pediatric Research, 6(2).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human MAP2 ELISA Kit (CAT#: V2LY-0626-LY1559)

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Isotype control

For research use only. Not intended for any clinical use.

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