Rat Mcam ELISA Kit (V2LY-0626-LY1857)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.33 ng/mL
Detection Range
0.5-150 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
71.3 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Melanoma Cell Adhesion Molecule
Function
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
Angiogenesis Source: MGI
Cell adhesion Source: ProtInc
Glomerular filtration Source: UniProtKB
Positive regulation of cell migration Source: Ensembl
Vascular wound healing Source: UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 24-559
Helical: 560-583
Cytoplasmic: 584-646

Pang, Y., Maxwell, E., Sindrewicz-Goral, P., Shapanis, A., Li, S., Morgan, M., & Yu, L. G. (2022). Galectin-3 Is a Natural Binding Ligand of MCAM (CD146, MUC18) in Melanoma Cells and Their Interaction Promotes Melanoma Progression. Biomolecules, 12(10), 1451.

Ikeguchi, R., Shimizu, Y., Kondo, A., Kanda, N., So, H., Kojima, H., & Kitagawa, K. (2021). Melanoma cell adhesion molecule expressing helper T cells in CNS inflammatory demyelinating diseases. Neurology-Neuroimmunology Neuroinflammation, 8(6).

Wang, Z., Xu, Q., Zhang, N., Du, X., Xu, G., & Yan, X. (2020). CD146, from a melanoma cell adhesion molecule to a signaling receptor. Signal transduction and targeted therapy, 5(1), 148.

Petersen, E. R., Ammitzbøll, C., Søndergaard, H. B., Oturai, A. B., Sørensen, P. S., Nilsson, A. C., ... & Sellebjerg, F. (2019). Expression of melanoma cell adhesion molecule-1 (MCAM-1) in natalizumab-treated multiple sclerosis. Journal of Neuroimmunology, 337, 577085.

Chen, Y., Sumardika, I. W., Tomonobu, N., Ruma, I. M. W., Kinoshita, R., Kondo, E., ... & Sakaguchi, M. (2019). Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion. Cancer Letters, 452, 178-190.

Čorić, M. (2019). Development and characterisation of monoclonal antibodies to tumour endothelial marker ‘melanoma cell adhesion molecule’(MCAM) and approaches to targeting MCAM on tumour vessels (Doctoral dissertation, University of Birmingham).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Mcam ELISA Kit (CAT#: V2LY-0626-LY2151)

Human Recombinant MCAM protein, hFc Tag (CAT#: V2LY-0526-LY2663)

Human Recombinant MCAM protein, His Tag (CAT#: V2LY-0526-LY2664)

Human Recombinant MCAM protein, His Tag-1 (CAT#: V2LY-0526-LY2665)

Human Recombinant MCAM protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY2666)

Mouse Recombinant MCAM protein, His Tag (CAT#: V2LY-0526-LY7942)

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Mouse Anti-MCAM Recombinant Antibody (7H217) (CAT#: CBMAB-C12041-LY)

Mouse Anti-MCAM Recombinant Antibody (CBWJC-4135) (CAT#: CBMAB-C5479WJ)

Rabbit Anti-MCAM Recombinant Antibody (CBYY-C2654) (CAT#: CBMAB-C4095-YY)

Rabbit Anti-MCAM Recombinant Antibody (CBFYC-2941) (CAT#: CBMAB-C3017-FY)

Mouse Anti-MCAM (AA 19-560) Recombinant Antibody (CBFYM-0142) (CAT#: CBMAB-M0163-FY)

Mouse Recombinant MCAM protein, His Tag (CAT#: V2LY-0526-LY7942)

Mouse Anti-MCAM Recombinant Antibody (CBFYC-0014) (CAT#: CBMAB-C0020-FY)

Isotype control

For research use only. Not intended for any clinical use.

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