Rat MMP1 ELISA Kit (V2LY-0626-LY699)

Name: Rat MMP1 ELISA Kit
SKU: V2LY-0626-LY699
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.05 ng/mL

Detection Range

0.1-30 ng/mL

Sample Type

Serum, Plasma, Urine, Ascites, Cerebrospinal fluid, Tissue

Specificity

Rat

Assay Type

Sandwich

Reactivity

Rat

Assay Time

1.5 h

Components

Standard Solution: 0.5ml x1
Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard Diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop Solution: 6ml x1
Substrate Solution A: 6ml x1
Substrate Solution B: 6ml x1
Wash Buffer Concentrate (25x): 20ml x1
Biotinylated Antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Matrix Metallopeptidase 1

Function

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757).

In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369).

Biological Process

Cellular protein metabolic process Source: Reactome
Cellular response to UV-A Source: UniProtKB
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Positive regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Proteolysis Source: ParkinsonsUK-UCL

Cellular Location

Extracellular matrix

PTM

Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.
Tyrosine phosphorylated in platelets by PKDCC/VLK.

Bartold, K., Iskierko, Z., Borowicz, P., Noworyta, K., Lin, C. Y., Kalecki, J., ... & Kutner, W. (2022). Molecularly imprinted polymer-based extended-gate field-effect transistor (EG-FET) chemosensor for selective determination of matrix metalloproteinase-1 (MMP-1) protein. Biosensors and Bioelectronics, 208, 114203.

Alwan, I. T., & Ghali, K. H. (2021). Association Risk of Metalomatrix Proteinase Enzymes Levels (MMP-1, MMP-9 And MMP-13) with Development of Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 11369-11378.

Cárcel-Márquez, J., Cullell, N., Muiño, E., Gallego-Fabrega, C., Lledós, M., Ibañez, L., ... & Fernandez-Cadenas, I. (2021). Causal effect of MMP-1 (matrix metalloproteinase-1), MMP-8, and MMP-12 levels on ischemic stroke: a Mendelian randomization study.

Wang, M., Zhou, Y., Huang, W., Zeng, Y., & Li, X. (2020). Association between matrix metalloproteinase-1 (MMP-1) protein level and the risk of rheumatoid arthritis and osteoarthritis: a meta-analysis. Brazilian Journal of Medical and Biological Research, 54, e10366.

Balkhi, S., Mashayekhi, F., Salehzadeh, A., & Saedi, H. S. (2020). Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and-3 serum concentration and associates with breast cancer. Molecular Biology Reports, 47(12), 9637-9644.

Mohammadian, H., Sharifi, R., Amirdehi, S. R., Taheri, E., & Bedoustani, A. B. (2020). Matrix metalloproteinase MMP1 and MMP9 genes expression in breast cancer tissue. Gene Reports, 21, 100906.

Zamolo, G., Grahovac, M., Žauhar, G., Vučinić, D., Kovač, L., Brajenić, N., & Grahovac, B. (2020). Matrix metalloproteinases MMP‐1, MMP‐2, and MMP‐13 are overexpressed in primary nodular melanoma. Journal of cutaneous pathology, 47(2), 139-145.

Chang, Y. T., Chu, L. J., Liu, Y. C., Chen, C. J., Wu, S. F., Chen, C. H., ... & Yu, J. S. (2020). Verification of saliva matrix metalloproteinase-1 as a strong diagnostic marker of oral cavity cancer. Cancers, 12(8), 2273.

Szóstek-Mioduchowska, A., Słowińska, M., Pacewicz, J., Skarzynski, D. J., & Okuda, K. (2020). Matrix metallopeptidase expression and modulation by transforming growth factor-β1 in equine endometrosis. Scientific Reports, 10(1), 1119.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant MMP1 protein, His Tag (CAT#: V2LY-0526-LY5610)

Human MMP1 ELISA Kit (CAT#: V2LY-0626-LY1262)

MMP1 Matched Antibody Pair (740) (CAT#: APMAB-740LY)

Antibody Pairs

MMP1 Matched Antibody Pair (740) (CAT#: APMAB-740LY)

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Human Recombinant MMP1 protein, His Tag (CAT#: V2LY-0526-LY5610)

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MMP1 Matched Antibody Pair (740) (CAT#: APMAB-740LY)

Mouse Anti-MMP1 Recombinant Antibody (3B8D12) (CAT#: CBMAB-0174-CN)

Mouse Anti-MMP1 Recombinant Antibody (CBT889) (CAT#: V2LY-0625-LY3195)

Mouse Anti-MMP1 Recombinant Antibody (A1136) (CAT#: CBMAB-AP4387LY)

Mouse Anti-MMP1 Recombinant Antibody (CBFYM-0661) (CAT#: CBMAB-M0797-FY)

Recombinant Mouse Anti-MMP1 Recombinant Antibody (5C10) (CAT#: CBMAB-XB0819-YC)

Mouse Anti-MMP1 Recombinant Antibody (CBFYM-0193) (CAT#: CBMAB-M0229-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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