Rat Recombinant CDH17 protein, His Tag (V2LY-0526-LY9191)

Name: Rat Recombinant CDH17 protein, His Tag
SKU: V2LY-0526-LY9191
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

His Tag

Protein Construction

This product is Rat Recombinant CDH17 protein, His Tag consist of Amino Acid: 1-786 and predicts a molecular mass of 86.4 kDa.

Molecule Mass

86.4 kDa

Verified

HPLC

Sequence

Amino Acid: 1-786

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥81% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cadherin 17

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.

Biological Process

Adherens junction organization Source: Reactome
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Germinal center B cell differentiation Source: Ensembl
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Marginal zone B cell differentiation Source: Ensembl
Oligopeptide transmembrane transport Source: UniProtKB
Oligopeptide transport Source: UniProtKB
Positive regulation of integrin activation by cell surface receptor linked signal transduction Source: UniProtKB
Spleen development Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 23-787
Helical: 788-808
Cytoplasmic: 809-832

Gray, M. E., & Sotomayor, M. (2021). Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism. Acta Crystallographica Section F: Structural Biology Communications, 77(3).

Zheng, B., Shen, S., Wong, T. K., Gong, Z. J., Sun, W., Ni, X., ... & Suo, T. (2021). Clinical correlation of cadherin-17 (CA17 aka CDH17) marker with advanced tumor stages and poor prognosis of cholangiocarcinoma in a retrospective cohort of 180 patients.

Lum, Y. L., Luk, J. M., Staunton, D. E., Ng, D. K., & Fong, W. P. (2020). Cadherin-17 Targeted near-infrared photoimmunotherapy for treatment of gastrointestinal cancer. Molecular Pharmaceutics, 17(10), 3941-3951.

Atukorala, I., & Mathivanan, S. (2018). PO-066 Knockdown of cadherin 17 inactivates WNT signalling pathway and induces apoptosis in colorectal cancer cells. ESMO Open, 3, A47.

Chang, Y. Y., Yu, L. C. H., Yu, I. S., Jhuang, Y. L., Huang, W. J., Yang, C. Y., & Jeng, Y. M. (2018). Deletion of cadherin‐17 enhances intestinal permeability and susceptibility to intestinal tumour formation. The Journal of pathology, 246(3), 289-299.

Lee, C. W., Lin, S. E., Tsai, H. I., Su, P. J., Hsieh, C. H., Kuo, Y. C., ... & Yu, M. C. (2018). Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19‑positive hepatocellular carcinoma. Oncology letters, 15(1), 559-567.

Tian, X., Han, Z., Zhu, Q., Tan, J., Liu, W., Wang, Y., ... & Huang, X. (2018). Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells. Biomedicine & Pharmacotherapy, 108, 331-337.

Bian, T., Zhao, J., Feng, J., Zhang, Q., Qian, L., Liu, J., ... & Zhang, J. (2017). Combination of cadherin-17 and SATB homeobox 2 serves as potential optimal makers for the differential diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma. Oncotarget, 8(38), 63442.

Shek, F. H., Luo, R., Lam, B. Y., Sung, W. K., Lam, T. W., Luk, J. M., ... & Lee, N. P. (2017). Serine peptidase inhibitor Kazal type 1 (SPINK1) as novel downstream effector of the cadherin-17/β-catenin axis in hepatocellular carcinoma. Cellular Oncology, 40(5), 443-456.

Smith, A. R., Rota, I. A., Maio, S., Massaad, M. J., Lund, T. C., Notarangelo, L. D., ... & Blazar, B. R. (2017). Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT. Blood advances, 1(23), 2083.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant CDH17 protein, ECD, His Tag (CAT#: V2LY-0526-LY1208)

Cynomolgus Recombinant CDH17 protein, hFc Tag (CAT#: V2LY-0526-LY1393)

Cynomolgus Recombinant CDH17 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1394)

Cynomolgus Recombinant CDH17 protein, His Tag (CAT#: V2LY-0526-LY1395)

Cynomolgus Recombinant CDH17 protein, His Tag-1 (CAT#: V2LY-0526-LY1396)

Cynomolgus Recombinant CDH17 protein, Fc Tag (CAT#: V2LY-0526-LY1397)

Human Recombinant CDH17 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY2489)

Human Recombinant CDH17 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2490)

Human Recombinant CDH17 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY2491)

Human Recombinant CDH17 protein, His Tag (CAT#: V2LY-0526-LY2492)

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Human Recombinant CDH17 protein, His Tag (CAT#: V2LY-0526-LY2492)

Mouse Anti-CDH17 Recombinant Antibody (CBT3903) (CAT#: V2LY-0625-LY169)

Cynomolgus Recombinant CDH17 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1394)

Rhesus Recombinant CDH17 protein, ECD, His Tag (CAT#: V2LY-0526-LY9655)

Human Recombinant CDH17 protein, His Tag-1 (CAT#: V2LY-0526-LY2493)

Cynomolgus Recombinant CDH17 protein, His Tag-1 (CAT#: V2LY-0526-LY1396)

Human Recombinant CDH17 protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY2496)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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