Rat Recombinant FCGR2A protein, ECD, hFc Tag (V2LY-0526-LY9233)

Name: Rat Recombinant FCGR2A protein, ECD, hFc Tag
SKU: V2LY-0526-LY9233
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

hFc Tag

Protein Construction

This product is Rat Recombinant FCGR2A protein, ECD, hFc Tag consist of Amino Acid: 1-216 and predicts a molecular mass of 47.5 kDa.

Molecule Mass

47.5 kDa

Protein Domain

ECD

Sequence

Amino Acid: 1-216

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fc Fragment Of IgG Receptor IIa

Research Area

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune system process Source: UniProtKB-KW
Regulation of immune response Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 34-217
Helical: 218-240
Cytoplasmic: 241-317

PTM

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.

Dahlqvist, J., Fulco, C. P., Ray, J. P., Liechti, T., de Boer, C. G., Lieb, D. J., ... & Hacohen, N. (2022). Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease. Human Molecular Genetics, 31(12), 1946-1961.

Paul, P., Picard, C., Lyonnet, L., Resseguier, N., Hubert, L., Arnaud, L., ... & Bonello, L. (2022). FCGR2A-HH Gene Variants Encoding the Fc Gamma Receptor for the C-Reactive Protein Are Associated with Enhanced Monocyte CD32 Expression and Cardiovascular Events’ Recurrence after Primary Acute Coronary Syndrome. Biomedicines, 10(2), 495.

Márquez Pete, N., Maldonado Montoro, M. D. M., Pérez Ramírez, C., Martínez Martínez, F., Martínez de la Plata, J. E., Daddaoua, A., & Jiménez Morales, A. (2021). Influence of the FCGR2A rs1801274 and FCGR3A rs396991 Polymorphisms on Response to Abatacept in Patients with Rheumatoid Arthritis. Journal of personalized medicine, 11(6), 573.

Ferdosian, F., Dastgheib, S. A., Hosseini-Jangjou, S. H., Nafei, Z., Lookzadeh, M. H., Noorishadkam, M., ... & Neamatzadeh, H. (2021). Association of TNF-α rs1800629, CASP3 rs72689236 and FCGR2A rs1801274 polymorphisms with susceptibility to Kawasaki disease: a comprehensive meta-analysis. Fetal and pediatric pathology, 40(4), 320-336.

Dai, Y., Chen, W., Huang, J., & Cui, T. (2021). FCGR2A Could Function as a Prognostic Marker and Correlate with Immune Infiltration in Head and Neck Squamous Cell Carcinoma. BioMed Research International, 2021.

Shi, X., Ma, Y., Li, H., & Yu, H. (2020). Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility. BMC medical genetics, 21(1), 1-13.

Sim, B. K., Park, H., Kim, J. J., Yun, S. W., Yu, J. J., Yoon, K. L., ... & Lee, J. K. (2019). Assessment of the clinical heterogeneity of Kawasaki disease using genetic variants of BLK and FCGR2A. Korean Circulation Journal, 49(1), 99-108.

Paul, P., Pedini, P., Lyonnet, L., Di Cristofaro, J., Loundou, A., Pelardy, M., ... & Picard, C. (2019). FCGR3A and FCGR2A genotypes differentially impact allograft rejection and patients' survival after lung transplant. Frontiers in Immunology, 10, 1208.

Jiménez Morales, A., Maldonado‐Montoro, M., Martinez de la Plata, J. E., Pérez Ramírez, C., Daddaoua, A., Alarcón Payer, C., ... & Garcia Collado, C. (2019). FCGR2A/FCGR3A gene polymorphisms and clinical variables as predictors of response to tocilizumab and rituximab in patients with rheumatoid arthritis. The Journal of Clinical Pharmacology, 59(4), 517-531.

Xia, S. L., Lin, D. P., Lin, Q. R., Sun, L., Wang, X. Q., Hong, W. J., ... & Jiang, Y. (2018). A Case–Control Study on Association of Ulcerative Colitis with FCGR2A Gene Polymorphisms in Chinese Patients. Genetic Testing and Molecular Biomarkers, 22(10), 607-614.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Human Recombinant FCGR2A (H167) protein, His Tag (CAT#: V2LY-0526-LY2802)

Human Recombinant FCGR2A (H167) protein, His Tag-1 (CAT#: V2LY-0526-LY2803)

Human Recombinant FCGR2A (H167) protein, hFc Tag (CAT#: V2LY-0526-LY2804)

Human Recombinant FCGR2A (H167) protein, Biotin Conjugated, His & AVI Tag-2 (CAT#: V2LY-0526-LY2805)

Human Recombinant FCGR2A (H167) protein, His Tag-2 (CAT#: V2LY-0526-LY2806)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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