Rat Recombinant SPN protein, hFc Tag (V2LY-0526-LY9246)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4+ T-cells and to a lesser extent by CD8+ T-cells (PubMed:18036228).
Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034).
Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).
CD43 cytoplasmic tail
Protects cells from apoptotic signals, promoting cell survival.
Biological Process cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process chemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process defense response to bacteriumManual Assertion Based On ExperimentIDA:MGI
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentTAS:ProtInc
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte tethering or rollingISS:UniProtKB
Biological Process negative regulation of cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of T cell proliferationISS:UniProtKB
Biological Process positive regulation of T cell migrationISS:UniProtKB
Biological Process positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of immune responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of T cell migrationISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process T-helper 1 cell lineage commitmentManual Assertion Based On ExperimentIDA:UniProtKB
Cell projection, microvillus
Cell projection, uropodium
Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN).
CD43 cytoplasmic tail
Nucleus
Nucleus, PML body
The sumoylated form localizes to the PML body.
Helical: 254-276
Cytoplasmic: 277-400
Phosphorylation at Ser-355 is regulated by chemokines, requires its association with ERM proteins (EZR, RDX and MSN) and is essential for its function in the regulation of T-cell trafficking to lymph nodes.
Has a high content of sialic acid and O-linked carbohydrate structures.
Cleavage by CTSG releases its extracellular domain and triggers its intramembrane proteolysis by gamma-secretase releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus.
CD43 cytoplasmic tail
Sumoylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Mouse Recombinant CD43 protein, hFc Tag (CAT#: V2LY-0526-LY8025)
Antibody Pairs
SPN Matched Antibody Pair (1133) (CAT#: APMAB-1133LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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