Rhesus Recombinant LIFR protein, His Tag (V2LY-0526-LY9767)

Name: Rhesus Recombinant LIFR protein, His Tag
SKU: V2LY-0526-LY9767
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rhesus

Tag

His Tag

Protein Construction

This product is Rhesus Recombinant LIFR protein, His Tag consist of Amino Acid: 1-833 and predicts a molecular mass of 90.95 kDa.

Molecule Mass

90.95 kDa

Verified

HPLC

Sequence

Amino Acid: 1-833

Species

Rhesus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

leukemia inhibitory factor receptor alpha

Function

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

Biological Process

Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Ciliary neurotrophic factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Leukemia inhibitory factor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Response to cytokineManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Isoform 1:
Cell membran
Isoform 2:
Secreted

Involvement in disease

Stueve-Wiedemann syndrome (STWS):
Severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue.
A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1.

Topology

Extracellular: 45-833
Helical: 834-858
Cytoplasmic: 859-1097

Di Giorgio, C., Bellini, R., Lupia, A., Massa, C., Bordoni, M., Marchianò, S., ... & Fiorucci, S. (2023). Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma. Frontiers in Oncology, 13, 1140730.

Di Giorgio, C., Morretta, E., Lupia, A., Bellini, R., Massa, C., Urbani, G., ... & Fiorucci, S. (2023). Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in Oncogenesis. bioRxiv, 2023-09.

Christianson, J., Oxford, J. T., & Jorcyk, C. L. (2021). Emerging perspectives on leukemia inhibitory factor and its receptor in cancer. Frontiers in Oncology, 11, 693724.

Vaziri, N., Shariati, L., Zarrabi, A., Farazmand, A., & Haghjooy Javanmard, S. (2021). Cancer-associated fibroblasts regulate the plasticity of breast cancer stemness through the production of leukemia inhibitory factor. Life, 11(12), 1298.

Wang, T., Yan, R., Xu, X., Yu, H., Wu, J., Yang, Y., & Li, W. (2019). Effects of leukemia inhibitory factor receptor on the adipogenic differentiation of human bone marrow mesenchymal stem cells. Molecular Medicine Reports, 19(6), 4719-4726.

Lei, C., Lv, S., Wang, H., Liu, C., Zhai, Q., Wang, S., ... & Wei, Q. (2018). Leukemia inhibitory factor receptor suppresses the metastasis of clear cell renal cell carcinoma through negative regulation of the yes-associated protein. DNA and Cell Biology, 37(8), 659-669.

Davis, S. M., & Pennypacker, K. R. (2018). The role of the leukemia inhibitory factor receptor in neuroprotective signaling. Pharmacology & therapeutics, 183, 50-57.

Li, X., Yang, Y., Yan, R., Xu, X., Gao, L., Mei, J., ... & Wang, T. (2018). miR-377-3p regulates adipogenic differentiation of human bone marrow mesenchymal stem cells by regulating LIFR. Molecular and Cellular Biochemistry, 449, 295-303.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LIFR protein, ECD, hFc Tag (CAT#: V2LY-0526-LY5296)

Human Recombinant LIFR protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY5297)

Human Recombinant LIFR protein, His Tag (CAT#: V2LY-0526-LY5298)

Rat Recombinant LIFR protein, His Tag (CAT#: V2LY-0526-LY9509)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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