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LYZ

This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis.
Full Name
LYZ
Function
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Biological Process
Antimicrobial humoral responseTAS:Reactome
CytolysisIEA:UniProtKB-KW
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Metabolic processIEA:UniProtKB-KW
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Secreted
Involvement in disease
Amyloidosis 8 (AMYL8):
A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.

Anti-LYZ antibodies

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Human Anti-LYZ Recombinant Antibody (CBFYH-3616) (CBMAB-H4174-FY)

Datasheet SDS
Target: LYZ
Host: Human
Specificity: Chicken
Clone: CBFYH-3616
Application*: WB

Mouse Anti-LYZ Recombinant Antibody (CBYJL-2280) (CBMAB-L2561-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2280
Application*: E, WB

Mouse Anti-LYZ Recombinant Antibody (LZ598-10G9) (CBMAB-L2560-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LZ598-10G9
Application*: F

Mouse Anti-LYZ Recombinant Antibody (LYZ-Z) (CBMAB-L2558-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LYZ-Z
Application*: F, IF, C, P

Rabbit Anti-LYZ Recombinant Antibody (EPR2994(2)) (CBMAB-L2556-YJ)

Datasheet SDS
Target: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPR2994(2)
Application*: P

Mouse Anti-LYZ Recombinant Antibody (CBYJL-2279) (CBMAB-L2555-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2279
Application*: E, F, P

Mouse Anti-LYZ Recombinant Antibody (CBYJL-2276) (CBMAB-L2552-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2276
Application*: E

Mouse Anti-LYZ Recombinant Antibody (CBYJL-2275) (CBMAB-L2551-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2275
Application*: E, P

Mouse Anti-LYZ Recombinant Antibody (CBYJL-2273) (CBMAB-L2545-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2273
Application*: WB, E

Mouse Anti-LYZ Recombinant Antibody (5F244) (CBMAB-L2544-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F244
Application*: F, IH

Mouse Anti-LYZ Recombinant Antibody (1D8) (CBMAB-L2541-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D8
Application*: IF, WB

Mouse Anti-LYZ Recombinant Antibody (CBYJL-2271) (CBMAB-L2540-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-2271
Application*: P, WB

Mouse Anti-LYZ Recombinant Antibody (CBYJL-2270) (CBMAB-L2539-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Frog
Clone: CBYJL-2270
Application*: IH, WB

Mouse Anti-LYZ Recombinant Antibody (10D407) (CBMAB-L2538-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10D407
Application*: E, IH

Mouse Anti-LYZ Recombinant Antibody (10D406) (CBMAB-L2537-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10D406
Application*: E, F, IH

Mouse Anti-LYZ Recombinant Antibody (CBYJL-2268) (CBMAB-L2533-YJ)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2268
Application*: E

Rabbit Anti-LYZ Recombinant Antibody (A971) (CBMAB-AP11580LY)

Datasheet SDS
Target: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A971
Application*: ICC, IF, IHC, WB

Rabbit Anti-LYZ Recombinant Antibody (A970) (CBMAB-AP11581LY)

Datasheet SDS
Target: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A970
Application*: ICC, IF, IHC, IP, WB

Recombinant Rabbit Anti-LYZ Antibody (CBAb157) (CBMAB-Ab157-LY)

Datasheet SDS
Target: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb157
Application*: WB, IH, IF, IP

Rabbit Anti-LYZ Recombinant Antibody (CBYCL-609) (CBMAB-L0510-YC)

Datasheet SDS
Target: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCL-609
Application*: WB, P, IF, IC, IP

Mouse Anti-LYZ Recombinant Antibody (CBYCL-608) (CBMAB-L0509-YC)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-608
Application*: WB, IC, P, C, E

Mouse Anti-LYZ Recombinant Antibody (CBYCL-607) (CBMAB-L0508-YC)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-607
Application*: WB, IC, P, C, E

Mouse Anti-LYZ Recombinant Antibody (CBYCL-606) (CBMAB-L0507-YC)

Datasheet SDS
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCL-606
Application*: E, F, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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