LYZ
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis.
Full Name
LYZ
Function
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Biological Process
Antimicrobial humoral responseTAS:Reactome
CytolysisIEA:UniProtKB-KW
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Metabolic processIEA:UniProtKB-KW
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
CytolysisIEA:UniProtKB-KW
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Metabolic processIEA:UniProtKB-KW
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Secreted
Involvement in disease
Amyloidosis 8 (AMYL8):
A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
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Anti-LYZ antibodies
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CompareTarget: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCL-609
Application*: WB, P, IF, IC, IP
Target: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A971
Application*: ICC, IF, IHC, WB
Target: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A970
Application*: ICC, IF, IHC, IP, WB
Target: LYZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb157
Application*: WB, IH, IF, IP
Target: LYZ
Host: Human
Specificity: Chicken
Clone: CBFYH-3616
Application*: WB
Target: LYZ
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-608
Application*: WB, IC, P, C, E
Target: LYZ
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-607
Application*: WB, IC, P, C, E
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCL-606
Application*: E, F, IH
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2280
Application*: E, WB
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LZ598-10G9
Application*: F
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LYZ-Z
Application*: F, IF, C, P
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2279
Application*: E, F, P
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2276
Application*: E
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2275
Application*: E, P
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2273
Application*: WB, E
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F244
Application*: F, IH
Target: LYZ
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D8
Application*: IF, WB
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-2271
Application*: P, WB
Target: LYZ
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Frog
Clone: CBYJL-2270
Application*: IH, WB
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10D407
Application*: E, IH
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10D406
Application*: E, F, IH
Target: LYZ
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2268
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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