Acaa2

The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq]
Full Name
acetyl-Coenzyme A acyltransferase 2
Function
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
Biological Process
Cellular response to hypoxia
Cholesterol biosynthetic process
Fatty acid beta-oxidation
Negative regulation of mitochondrial membrane permeability involved in apoptotic process
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular Location
Mitochondrion
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Anti-Acaa2 antibodies

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Rabbit Anti-ACAA2 Recombinant Antibody (
12F4) (V2LY-0725-LY1558)

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Target: ACAA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 12F4
Application*: E, WB, IH, IF
Datasheet SDS

Mouse Anti-ACAA2 Recombinant Antibody (V2-179154) (CBMAB-A0409-YC)

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Target: ACAA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179154
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-ACAA2 Recombinant Antibody (V2-179153) (CBMAB-A0408-YC)

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Target: ACAA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: V2-179153
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-ACAA2 Recombinant Antibody (V2-179152) (CBMAB-A0407-YC)

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Target: ACAA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179152
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-ACAA2 Recombinant Antibody (V2-179151) (CBMAB-A0406-YC)

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Target: ACAA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179151
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-ACAA2 Recombinant Antibody (V2-179149) (CBMAB-A0404-YC)

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Target: ACAA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179149
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-ACAA2 Recombinant Antibody (V2-179148) (CBMAB-A0403-YC)

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Target: ACAA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179148
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-ACAA2 Recombinant Antibody (V2-179146) (CBMAB-A0401-YC)

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Target: ACAA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179146
Application*: IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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