Acaa2
The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal. [provided by RefSeq]
Full Name
acetyl-Coenzyme A acyltransferase 2
Function
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
Biological Process
Cellular response to hypoxia
Cholesterol biosynthetic process
Fatty acid beta-oxidation
Negative regulation of mitochondrial membrane permeability involved in apoptotic process
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cholesterol biosynthetic process
Fatty acid beta-oxidation
Negative regulation of mitochondrial membrane permeability involved in apoptotic process
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular Location
Mitochondrion
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Anti-Acaa2 antibodies
+ Filters

Target: ACAA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179154
Application*: IF, P, WB
Target: ACAA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: V2-179153
Application*: WB, IH, IF
Target: ACAA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179152
Application*: IF, P, WB
Target: ACAA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179151
Application*: IF, P, WB
Target: ACAA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179149
Application*: IF, P, WB
Target: ACAA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179148
Application*: IF, IH, WB
Target: ACAA2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179146
Application*: IF, P, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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