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Mouse Anti-ACAA2 Recombinant Antibody (V2-179153) (CBMAB-A0408-YC)

Provided herein is a Mouse monoclonal antibody against Human Acetyl-CoA Acyltransferase 2. The antibody can be used for immunoassay techniques, such as WB, IHC, IF.
See all ACAA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Monkey, Mouse
Clone
V2-179153
Antibody Isotype
IgG1
Application
WB, IHC, IF

Basic Information

Immunogen
Full length human recombinant protein of human ACAA2(NP_006102) produced in HEK293T cell
Specificity
Human, Dog, Rat, Monkey, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:200-1:4,000
IF(ICC)1:100
IHC-P1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Buffer
PBS, 1% BSA, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
acetyl-Coenzyme A acyltransferase 2
Introduction
The encoded protein catalyzes the last step of the mitochondrial fatty acid beta-oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal.
Entrez Gene ID
Human10449
Mouse52538
Rat170465
Monkey709350
Dog490568
UniProt ID
HumanP42765
MouseQ8BWT1
RatP13437
MonkeyH2QEI6
Alternative Names
Acetyl-CoA Acyltransferase 2; Mitochondrial 3-Oxoacyl-Coenzyme A Thiolase; Mitochondrial 3-Oxoacyl-CoA Thiolase; Acetyl-Coenzyme A Acyltransferase 2; EC 2.3.1.16; T1; 3-Ketoacyl-CoA Thiolase, Mitochondrial;
Function
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
Biological Process
Cellular response to hypoxia
Cholesterol biosynthetic process
Fatty acid beta-oxidation
Negative regulation of mitochondrial membrane permeability involved in apoptotic process
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular Location
Mitochondrion
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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