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ACOT13

This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

Full Name

Acyl-CoA Thioesterase 13

Function

Catalyzes the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (By similarity).

Biological Process

Acyl-CoA metabolic process
Negative regulation of cold-induced thermogenesis
Protein homotetramerization

Cellular Location

Nucleus; Mitochondrion; Spindle; Cytosol. During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin.

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Anti-ACOT13 antibodies

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Mouse Anti-ACOT13 Recombinant Antibody (V2-347934) (CBMAB-T0005-YJ)

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Target: ACOT13

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat, Mouse

Clone: V2-347934

Application*: WB, IP, IF, E

Mouse Anti-ACOT13 Recombinant Antibody (V2-347933) (CBMAB-T0004-YJ)

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Target: ACOT13

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-347933

Application*: WB, E

Human Recombinant ACOT13 protein, His Tag (V2LY-0526-LY1902)

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Target: ACOT13

Expressed Host: E. coli

Sequence: Amino Acid: 1-140

Tag: His Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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