ADAM19

ADAM19 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involvin

Full Name

ADAM Metallopeptidase Domain 19

Function

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).

Biological Process

Amyloid precursor protein catabolic process
Extracellular matrix organization
Membrane protein ectodomain proteolysis
Placenta development
Positive regulation of cell-cell adhesion mediated by cadherin
Positive regulation of gene expression
Protein processing

Cellular Location

Membrane

Topology

Extracellular: 203-699 aa
Helical: 700-720 aa
Cytoplasmic: 721-955 aa

PTM

The precursor is cleaved by a furin endopeptidase.

Anti-ADAM19 antibodies

Rat Anti-ADAM19 Recombinant Antibody (V2-179769) (CBMAB-A1131-YC)

Datasheet

SDS

Target: ADAM19

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: V2-179769

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)