ADAM19

ADAM19 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involvin

Full Name

ADAM Metallopeptidase Domain 19

Function

Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity).

Biological Process

Amyloid precursor protein catabolic process
Extracellular matrix organization
Membrane protein ectodomain proteolysis
Placenta development
Positive regulation of cell-cell adhesion mediated by cadherin
Positive regulation of gene expression
Protein processing

Cellular Location

Membrane

Topology

Extracellular: 203-699 aa
Helical: 700-720 aa
Cytoplasmic: 721-955 aa

PTM

The precursor is cleaved by a furin endopeptidase.