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ADGRE5

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

Full Name

Adhesion G Protein-Coupled Receptor E5

Function

Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell-cell signaling
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Immune response
Inflammatory response
Neutrophil degranulation

Cellular Location

Cell membrane
Adhesion G protein-coupled receptor E5 subunit alpha: Extracellular space

Topology

Extracellular: 21-552 aa
Helical: 553-572 aa
Cytoplasmic: 573-581 aa
Helical: 582-601 aa
Extracellular: 602-620 aa
Helical: 621-642 aa
Cytoplasmic: 643-653 aa
Helical: 654-674 aa
Extracellular: 675-691 aa
Helical: 692-712 aa
Cytoplasmic: 713-739 aa
Helical: 740-760 aa
Extracellular: 761-766 aa
Helical: 767-789 aa
Cytoplasmic: 790-835 aa

PTM

Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.

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Anti-ADGRE5 antibodies

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Mouse Anti-ADGRE5 Recombinant Antibody (V2-360335) (CBMAB-C2088-CQ)

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Target: ADGRE5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-360335

Application*: F, WB

Rat Anti-ADGRE5 Recombinant Antibody (V2-187291) (CBMAB-C7234-LY)

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Target: ADGRE5

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: V2-187291

Application*: F, MC

Human Recombinant CD97 protein, His Tag (V2LY-0526-LY2982)

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Target: ADGRE5

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-398

Tag: His Tag

Human Recombinant CD97 protein, hFc Tag (V2LY-0526-LY2981)

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Target: ADGRE5

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-398

Tag: hFc Tag

Rabbit Anti-ADGRE5 Recombinant Antibody (
3A7) (V2LY-0725-LY647)

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Target: ADGRE5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 3A7

Application*: E, IH, IF

Mouse Anti-ADGRE5 Recombinant Antibody (CBT2852) (V2LY-0625-LY1028)

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Target: ADGRE5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBT2852

Application*: IH, F

Rabbit Anti-ADGRE5 Recombinant Antibody (V2-335765) (CBMAB-C0069-FY)

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Target: ADGRE5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-335765

Application*: E, F, IC, IF

Mouse Anti-ADGRE5 Recombinant Antibody (V2-183826) (CBMAB-C1834-LY)

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Target: ADGRE5

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: V2-183826

Application*: E, IC/IF, IF

Mouse Anti-ADGRE5 Recombinant Antibody (V2-183326) (CBMAB-C1050-LY)

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Target: ADGRE5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: V2-183326

Application*: WB, F, N, MC

Functional Assay

Rat Anti-ADGRE5 Recombinant Antibody (V2-183239) (CBMAB-C0913-LY)

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Target: ADGRE5

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: V2-183239

Application*: F, MC

Mouse Anti-ADGRE5 Recombinant Antibody (V2-182711) (CBMAB-C0062-LY)

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Target: ADGRE5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: V2-182711

Application*: F, IC/IF, IF

Rabbit Anti-ADGRE5 Recombinant Antibody (V2-182705) (CBMAB-C0054-LY)

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Target: ADGRE5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-182705

Application*: E, F, IC/IF, IF

Mouse Anti-ADGRE5 Recombinant Antibody (V2-179884) (CBMAB-A1268-YC)

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Target: ADGRE5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: V2-179884

Application*: E, WB, IP, IF

Rabbit Anti-ADGRE5 Recombinant Antibody (V2-12525) (CBMAB-1015-CN)

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Target: ADGRE5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: V2-12525

Application*: F, IC, IF, P, IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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