ADGRE5

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
Full Name
Adhesion G Protein-Coupled Receptor E5
Function
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell-cell signaling
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Immune response
Inflammatory response
Neutrophil degranulation
Cellular Location
Cell membrane
Adhesion G protein-coupled receptor E5 subunit alpha: Extracellular space
Topology
Extracellular: 21-552 aa
Helical: 553-572 aa
Cytoplasmic: 573-581 aa
Helical: 582-601 aa
Extracellular: 602-620 aa
Helical: 621-642 aa
Cytoplasmic: 643-653 aa
Helical: 654-674 aa
Extracellular: 675-691 aa
Helical: 692-712 aa
Cytoplasmic: 713-739 aa
Helical: 740-760 aa
Extracellular: 761-766 aa
Helical: 767-789 aa
Cytoplasmic: 790-835 aa
PTM
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
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Anti-ADGRE5 antibodies

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Mouse Anti-ADGRE5 Recombinant Antibody (V2-360335) (CBMAB-C2088-CQ)

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Target: ADGRE5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-360335
Application*: F, WB
Datasheet SDS

Rat Anti-ADGRE5 Recombinant Antibody (V2-187291) (CBMAB-C7234-LY)

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Target: ADGRE5
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: V2-187291
Application*: F, MC
Datasheet SDS

Mouse Anti-ADGRE5 Recombinant Antibody (CBT2852) (V2LY-0625-LY1028)

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Target: ADGRE5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2852
Application*: IH, F
Datasheet SDS

Rabbit Anti-ADGRE5 Recombinant Antibody (V2-335765) (CBMAB-C0069-FY)

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Target: ADGRE5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-335765
Application*: E, F, IC, IF
Datasheet SDS

Mouse Anti-ADGRE5 Recombinant Antibody (V2-183826) (CBMAB-C1834-LY)

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Target: ADGRE5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-183826
Application*: E, IC/IF, IF
Datasheet SDS

Mouse Anti-ADGRE5 Recombinant Antibody (V2-183326) (CBMAB-C1050-LY)

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Target: ADGRE5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-183326
Application*: WB, F, N, MC
Functional Assay
Datasheet SDS

Rat Anti-ADGRE5 Recombinant Antibody (V2-183239) (CBMAB-C0913-LY)

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Target: ADGRE5
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: V2-183239
Application*: F, MC
Datasheet SDS

Mouse Anti-ADGRE5 Recombinant Antibody (V2-182711) (CBMAB-C0062-LY)

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Target: ADGRE5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-182711
Application*: F, IC/IF, IF
Datasheet SDS

Rabbit Anti-ADGRE5 Recombinant Antibody (V2-182705) (CBMAB-C0054-LY)

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Target: ADGRE5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-182705
Application*: E, F, IC/IF, IF
Datasheet SDS

Mouse Anti-ADGRE5 Recombinant Antibody (V2-179884) (CBMAB-A1268-YC)

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Target: ADGRE5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-179884
Application*: E, WB, IP, IF
Datasheet SDS

Rabbit Anti-ADGRE5 Recombinant Antibody (V2-12525) (CBMAB-1015-CN)

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Target: ADGRE5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: V2-12525
Application*: F, IC, IF, P, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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