AGXT

AGXT is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I pri
Full Name
Alanine-Glyoxylate Aminotransferase
Biological Process
Carboxylic acid metabolic process
Glycine biosynthetic process, by transamination of glyoxylate
Glyoxylate catabolic process
Glyoxylate metabolic process
L-alanine catabolic process
L-cysteine catabolic process
Protein localization
Pyruvate biosynthetic process
Response to cAMP
Response to glucocorticoid
Cellular Location
Peroxisome; Mitochondrion. Predominantly localized in the peroxisomes. Mitochondrial mistargeting occurs in variant proteins Arg-41, Arg-47, Ile-152, Arg-170 and Thr-244 associated with the disease HP1.
Involvement in disease
Hyperoxaluria primary 1 (HP1): An inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and progressive tissue accumulation of insoluble calcium oxalate. Affected individuals are at risk for nephrolithiasis, nephrocalcinosis and early onset end-stage renal disease.
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Anti-AGXT antibodies

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Rabbit Anti-AGXT Recombinant Antibody (V2-180259) (CBMAB-A1692-YC)

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Target: AGXT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: V2-180259
Application*: WB, IP, P
Datasheet SDS

Mouse Anti-AGXT Recombinant Antibody (V2-180256) (CBMAB-A1689-YC)

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Target: AGXT
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180256
Application*: E, WB
Datasheet SDS

Mouse Anti-AGXT Recombinant Antibody (V2-180255) (CBMAB-A1688-YC)

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Target: AGXT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: V2-180255
Application*: E, IC, IF
Datasheet SDS

Mouse Anti-AGXT Recombinant Antibody (1F9BC7) (CBMAB-A1687-YC)

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Target: AGXT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180254
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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