AGXT

AGXT is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I pri

Full Name

Alanine-Glyoxylate Aminotransferase

Biological Process

Carboxylic acid metabolic process
Glycine biosynthetic process, by transamination of glyoxylate
Glyoxylate catabolic process
Glyoxylate metabolic process
L-alanine catabolic process
L-cysteine catabolic process
Protein localization
Pyruvate biosynthetic process
Response to cAMP
Response to glucocorticoid

Cellular Location

Peroxisome; Mitochondrion. Predominantly localized in the peroxisomes. Mitochondrial mistargeting occurs in variant proteins Arg-41, Arg-47, Ile-152, Arg-170 and Thr-244 associated with the disease HP1.

Involvement in disease

Hyperoxaluria primary 1 (HP1): An inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and progressive tissue accumulation of insoluble calcium oxalate. Affected individuals are at risk for nephrolithiasis, nephrocalcinosis and early onset end-stage renal disease.

Anti-AGXT antibodies

Rabbit Anti-AGXT Recombinant Antibody (V2-180259) (CBMAB-A1692-YC)

Datasheet

SDS

Target: AGXT

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: V2-180259

Application*: WB, IP, P

Mouse Anti-AGXT Recombinant Antibody (V2-180256) (CBMAB-A1689-YC)

Datasheet

SDS

Target: AGXT

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: V2-180256

Application*: E, WB

Mouse Anti-AGXT Recombinant Antibody (V2-180255) (CBMAB-A1688-YC)

Datasheet

SDS

Target: AGXT

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: V2-180255

Application*: E, IC, IF

Mouse Anti-AGXT Recombinant Antibody (1F9BC7) (CBMAB-A1687-YC)

Datasheet

SDS

Target: AGXT

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180254

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)