ARFIP1

Putative target protein of ADP-ribosylation factor.
Full Name
ADP Ribosylation Factor Interacting Protein 1
Function
Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.
Biological Process
Intracellular protein transport Source: MGI
Negative regulation of retrograde transport, endosome to Golgi Source: CACAO
Regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
Regulation of protein secretion Source: MGI
Cellular Location
Golgi apparatus; Trans-Golgi network membrane
PTM
Phosphorylated by PRKD1; phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery.
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Anti-ARFIP1 antibodies

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Mouse Anti-ARFIP1 Recombinant Antibody (1F10) (CBMAB-A3455-YC)

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Target: ARFIP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F10
Application*: E, P, WB
Datasheet SDS

Mouse Anti-ARFIP1 Recombinant Antibody (EG225) (CBMAB-EN252-LY)

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Target: ARFIP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: EG225
Application*: WB, IP, IF, E
Datasheet SDS
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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