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ARFIP1

Putative target protein of ADP-ribosylation factor.

Full Name

ADP Ribosylation Factor Interacting Protein 1

Function

Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold. Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs. In turn, ARFs induce fission. Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells.

Biological Process

Intracellular protein transport Source: MGI
Negative regulation of retrograde transport, endosome to Golgi Source: CACAO
Regulation of Arp2/3 complex-mediated actin nucleation Source: GO_Central
Regulation of protein secretion Source: MGI

Cellular Location

Golgi apparatus; Trans-Golgi network membrane

PTM

Phosphorylated by PRKD1; phosphorylation delocalizes ARFIP1 from the Golgi and disrupts its ability to inhibit the activity of ADP-ribosylation factor, an important component of the vesicle scission machinery.

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Anti-ARFIP1 antibodies

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Mouse Anti-ARFIP1 Recombinant Antibody (1F10) (CBMAB-A3455-YC)

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Target: ARFIP1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1F10

Application*: E, P, WB

Mouse Anti-ARFIP1 Recombinant Antibody (EG225) (CBMAB-EN252-LY)

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Target: ARFIP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: EG225

Application*: WB, IP, IF, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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