ARHGDIB
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
Full Name
Rho GDP Dissociation Inhibitor Beta
Function
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369).
Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).
Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).
Biological Process
Cellular response to redox state Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of cell adhesion Source: ProtInc
Negative regulation of trophoblast cell migration Source: CACAO
Positive regulation of GTPase activity Source: GOC
Regulation of actin cytoskeleton reorganization Source: UniProtKB
Regulation of Rho protein signal transduction Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: GO_Central
Multicellular organism development Source: ProtInc
Negative regulation of cell adhesion Source: ProtInc
Negative regulation of trophoblast cell migration Source: CACAO
Positive regulation of GTPase activity Source: GOC
Regulation of actin cytoskeleton reorganization Source: UniProtKB
Regulation of Rho protein signal transduction Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: GO_Central
Cellular Location
Cytosol
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Anti-ARHGDIB antibodies
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Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 17
Application*: WB, IP, IF, E
Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A759
Application*: WB, IP, IF, E, P
Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYC-A758
Application*: WB, IP, IF, E
Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C12-B6
Application*: E
Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 97A1015
Application*: FC, WB, IH, IP
Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Cattle, Dog, Horse, Chicken
Clone: 10D774
Application*: FC, WB, IF
Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Cattle, Dog, Horse, Chicken, Pig
Clone: 8J1255
Application*: WB, IP, IF, E
Target: ARHGDIB
Sensitivity: 0.0073 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: ARHGDIB
Specificity: Human
Target: ARHGDIB
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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