ARHGDIB

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
Full Name
Rho GDP Dissociation Inhibitor Beta
Function
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369).
Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).
Biological Process
Cellular response to redox state Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of cell adhesion Source: ProtInc
Negative regulation of trophoblast cell migration Source: CACAO
Positive regulation of GTPase activity Source: GOC
Regulation of actin cytoskeleton reorganization Source: UniProtKB
Regulation of Rho protein signal transduction Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Rho protein signal transduction Source: GO_Central
Cellular Location
Cytosol
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Anti-ARHGDIB antibodies

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Mouse Anti-ARHGDIB Recombinant Antibody (17) (CBMAB-AP436LY)

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Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 17
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ARHGDIB Recombinant Antibody (CBYC-A759) (CBMAB-A3515-YC)

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Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A759
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-ARHGDIB Recombinant Antibody (CBYC-A758) (CBMAB-A3514-YC)

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Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYC-A758
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ARHGDIB Recombinant Antibody (2C12-B6) (CBMAB-A3513-YC)

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Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C12-B6
Application*: E
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Mouse Anti-ARHGDIB Recombinant Antibody (97A1015) (CBMAB-D0026-YC)

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Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 97A1015
Application*: FC, WB, IH, IP
Datasheet SDS

Mouse Anti-ARHGDIB Recombinant Antibody (10D774) (CBMAB-D0022-YC)

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Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Cattle, Dog, Horse, Chicken
Clone: 10D774
Application*: FC, WB, IF
Datasheet SDS

Mouse Anti-ARHGDIB Recombinant Antibody (8J1255) (CBMAB-D0021-YC)

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Target: ARHGDIB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Cattle, Dog, Horse, Chicken, Pig
Clone: 8J1255
Application*: WB, IP, IF, E
Datasheet SDS

ARHGDIB Matched Antibody Pair (103) (APMAB-103LY)

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Target: ARHGDIB
Specificity: Human
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ARHGDIB Matched Antibody Pair (102) (APMAB-102LY)

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Target: ARHGDIB
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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