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ARHGDIB Matched Antibody Pair (102) (APMAB-102LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ARHGDIB polyclonal antibody, 100 ug
Detection Antibody
Anti-ARHGDIB Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
Alternative Names
Rho GDP Dissociation Inhibitor Beta; Rho GDP Dissociation Inhibitor (GDI) Beta; Rho-GDI Beta; Rho GDI 2; RAP1GN1; Ly-GDI; GDIA2;
Entrez Gene ID
397
UniProt ID
P52566
More Infomation

Betjes, M. G., Sablik, K. A., Litjens, N. H., Otten, H. G., & de Weerd, A. E. (2021). ARHGDIB and AT1R autoantibodies are differentially related to the development and presence of chronic antibody-m

Wang, X., Bi, X., Huang, X., Wang, B., Guo, Q., & Wu, Z. (2020). Systematic investigation of biomarker-like role of ARHGDIB in breast cancer. Cancer Biomarkers, 28(1), 101-110.

Senev, A., Otten, H. G., Kamburova, E. G., Callemeyn, J., Lerut, E., Van Sandt, V., ... & Naesens, M. (2020). Antibodies against ARHGDIB and ARHGDIB gene expression associate with kidney allograft outcome. Transplantation, 104(7), 1462-1471.

Kardol-Hoefnagel, T., van Logtestijn, S. A., & Otten, H. G. (2020). A review on the function and regulation of ARHGDIB/RhoGDI2 expression including the hypothetical role of ARHGDIB/RhoGDI2 autoantibodies in kidney transplantation. Transplantation direct, 6(5).

Kamburova, E. G., Gruijters, M. L., Kardol‐Hoefnagel, T., Wisse, B. W., Joosten, I., Allebes, W. A., ... & Otten, H. G. (2019). Antibodies against ARHGDIB are associated with long‐term kidney graft loss. American Journal of Transplantation, 19(12), 3335-3344.

Cao, L., Lafyatis, R., & Burkly, L. C. (2017). Increased dermal collagen bundle alignment in systemic sclerosis is associated with a cell migration signature and role of Arhgdib in directed fibroblast migration on aligned ECMs. PloS one, 12(6), e0180751.

von Klot, C. A., Dubrowinskaja, N., Peters, I., Hennenlotter, J., Merseburger, A. S., Stenzl, A., ... & Serth, J. (2017). Rho GDP dissociation inhibitor‑β in renal cell carcinoma. Oncology letters, 14(6), 8190-8196.

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For research use only. Not intended for any clinical use.

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