ATRAID

ATRAID is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.

Full Name

All-Trans Retinoic Acid Induced Differentiation Factor

Function

Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of cellular protein catabolic process Source: UniProtKB
Negative regulation of osteoblast proliferation Source: UniProtKB
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of osteoblast differentiation Source: UniProtKB
Regulation of gene expression Source: UniProtKB

Cellular Location

Nucleus envelope; Cell membrane. Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284).

Topology

Extracellular: 31-199 aa
Helical: 200-220 aa
Cytoplasmic: 221-229 aa

Anti-ATRAID antibodies

Mouse Anti-ATRAID Recombinant Antibody (1D2) (CBMAB-A0975-LY)

Datasheet

SDS

Target: ATRAID

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1D2

Application*: E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)