ATRAID

ATRAID is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.

Full Name

All-Trans Retinoic Acid Induced Differentiation Factor

Function

Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of cellular protein catabolic process Source: UniProtKB
Negative regulation of osteoblast proliferation Source: UniProtKB
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of osteoblast differentiation Source: UniProtKB
Regulation of gene expression Source: UniProtKB

Cellular Location

Nucleus envelope; Cell membrane. Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284).

Topology

Extracellular: 31-199 aa
Helical: 200-220 aa
Cytoplasmic: 221-229 aa