AVPR1A

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq]

Full Name

arginine vasopressin receptor 1A

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.

Biological Process

Activation of phospholipase C activity Source: ProtInc
Blood circulation Source: ProtInc
Calcium-mediated signaling Source: Ensembl
Cellular response to water deprivation Source: Ensembl
Generation of precursor metabolites and energy Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Grooming behavior Source: Ensembl
Maternal aggressive behavior Source: Ensembl
Maternal behavior Source: Ensembl
Myotube differentiation Source: Ensembl
Negative regulation of female receptivity Source: Ensembl
Negative regulation of transmission of nerve impulse Source: Ensembl
Penile erection Source: Ensembl
Positive regulation of cell growth Source: Ensembl
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of cellular pH reduction Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Positive regulation of glutamate secretion Source: Ensembl
Positive regulation of heart rate Source: Ensembl
Positive regulation of prostaglandin biosynthetic process Source: Ensembl
Positive regulation of renal sodium excretion Source: Ensembl
Positive regulation of systemic arterial blood pressure Source: Ensembl
Positive regulation of vasoconstriction Source: GO_Central
Regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
Response to corticosterone Source: Ensembl
Social behavior Source: Ensembl
Sperm ejaculation Source: Ensembl
Telencephalon development Source: Ensembl
Transport across blood-brain barrier Source: ARUK-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 1-52 aa
Helical: 53-76 aa
Cytoplasmic: 77-88 aa
Helical: 89-110 aa
Extracellular: 111-125 aa
Helical: 126-147 aa
Cytoplasmic: 148-168 aa
Helical: 169-190 aa
Extracellular: 191-218 aa
Helical: 219-239 aa
Cytoplasmic: 240-293 aa
Helical: 294-313 aa
Extracellular: 314-331 aa
Helical: 332-351 aa
Cytoplasmic: 352-418 aa