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Rabbit Anti-AVPR1A Recombinant Antibody (1176) (CBMAB-1176-CN)

This product is a rabbit antibody that recognizes AVPR1A of human. The antibody EPR5642 can be used for immunoassay techniques such as: WB.
See all AVPR1A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
1176
Antibody Isotype
IgG
Application
WB, IF, IHC

Basic Information

Immunogen
Peptide corresponding to human AVPR1A (aa398-aa418).
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500
IF(ICC)1:500
IHC1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
arginine vasopressin receptor 1A
Introduction
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.
Entrez Gene ID
552
UniProt ID
P37288
Alternative Names
V1aR; AVPR1; AVPR V1a
Function
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.
Biological Process
Activation of phospholipase C activity Source: ProtInc
Blood circulation Source: ProtInc
Calcium-mediated signaling Source: Ensembl
Cellular response to water deprivation Source: Ensembl
Generation of precursor metabolites and energy Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Grooming behavior Source: Ensembl
Maternal aggressive behavior Source: Ensembl
Maternal behavior Source: Ensembl
Myotube differentiation Source: Ensembl
Negative regulation of female receptivity Source: Ensembl
Negative regulation of transmission of nerve impulse Source: Ensembl
Penile erection Source: Ensembl
Positive regulation of cell growth Source: Ensembl
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of cellular pH reduction Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: ProtInc
Positive regulation of glutamate secretion Source: Ensembl
Positive regulation of heart rate Source: Ensembl
Positive regulation of prostaglandin biosynthetic process Source: Ensembl
Positive regulation of renal sodium excretion Source: Ensembl
Positive regulation of systemic arterial blood pressure Source: Ensembl
Positive regulation of vasoconstriction Source: GO_Central
Regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
Response to corticosterone Source: Ensembl
Social behavior Source: Ensembl
Sperm ejaculation Source: Ensembl
Telencephalon development Source: Ensembl
Transport across blood-brain barrier Source: ARUK-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 1-52 aa
Helical: 53-76 aa
Cytoplasmic: 77-88 aa
Helical: 89-110 aa
Extracellular: 111-125 aa
Helical: 126-147 aa
Cytoplasmic: 148-168 aa
Helical: 169-190 aa
Extracellular: 191-218 aa
Helical: 219-239 aa
Cytoplasmic: 240-293 aa
Helical: 294-313 aa
Extracellular: 314-331 aa
Helical: 332-351 aa
Cytoplasmic: 352-418 aa

Vollebregt, O., Koyama, E., Zai, C. C., Shaikh, S. A., Lisoway, A. J., Kennedy, J. L., & Beitchman, J. H. (2021). Evidence for association of vasopressin receptor 1A promoter region repeat with childhood onset aggression. Journal of Psychiatric Research, 140, 522-528.

Weiss, A., Wilson, V. A., & Hopkins, W. D. (2021). Early social rearing, the V1A arginine vasopressin receptor genotype, and autistic traits in chimpanzees. Autism Research.

Ripoll, G. V., Pifano, M., Garona, J., & Alonso, D. F. (2020). Commentary: Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer. Frontiers in oncology, 9, 1490.

Nishina, K., Takagishi, H., Takahashi, H., Sakagami, M., & Inoue-Murayama, M. (2019). Association of polymorphism of arginine-vasopressin receptor 1A (AVPR1a) gene with trust and reciprocity. Frontiers in human neuroscience, 13, 230.

Zhao, N., Peacock, S. O., Lo, C. H., Heidman, L. M., Rice, M. A., Fahrenholtz, C. D., ... & Burnstein, K. L. (2019). Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer. Science translational medicine, 11(498).

Landefeld, C. C., Hodgkinson, C. A., Spagnolo, P. A., Marietta, C. A., Shen, P. H., Sun, H., ... & Goldman, D. (2018). Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. Translational psychiatry, 8(1), 1-10.

Albee, L. J., LaPorte, H. M., Gao, X., Eby, J. M., Cheng, Y. H., Nevins, A. M., ... & Majetschak, M. (2018). Identification and functional characterization of arginine vasopressin receptor 1A: atypical chemokine receptor 3 heteromers in vascular smooth muscle. Open biology, 8(1), 170207.

Zhao, N., Peacock, S., Lo, C. H., Heidman, L., Magani, F., Rice, M., ... & Burnstein, K. (2018). Abstract A063: Preclinical evaluation of an arginine vasopressin receptor 1A (AVPR1A) antagonist in castration-resistant prostate cancer.

Wilson, V. A., Weiss, A., Humle, T., Morimura, N., Udono, T., Idani, G. I., ... & Inoue-Murayama, M. (2017). Chimpanzee personality and the arginine vasopressin receptor 1A genotype. Behavior Genetics, 47(2), 215-226.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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