BCL2L14

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]

BCL2 Like 14

Plays a role in apoptosis.

Apoptotic process Source: UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Regulation of apoptotic process Source: Reactome
Regulation of extrinsic apoptotic signaling pathway Source: GO_Central

Cytoplasm
Isoform 1: Cytosol. Diffusely distributed throughout the cytosol.
Isoform 2: Endomembrane system. Predominantly localized to cytosolic organelles.

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.