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Mouse Anti-BCL2L14 Recombinant Antibody (CBYY-0421) (CBMAB-0423-YY)

This product is mouse antibody that recognizes BCL2L14. The antibody CBYY-0421 can be used for immunoassay techniques such as: ELISA, WB
See all BCL2L14 antibodies
Published Data
Mouse Anti-BCL2L14 Recombinant Antibody (CBYY-0421) (CBMAB-0423-YY) in WB and IF
In vitro and in situ interactions of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl-G with dcTPR proteins. (A) Coomassie blue R staining of overexpressed and purified proteins used in GST pull-down assay. (B) Western blot analysis of GST-AIP and GST-FKBP51 pull-down of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105, Bcl-G and their truncated versions lacking five utmost C-terminal residues. (C) PLA of Usp19, DNAAF2, NADSYN1, p23/PTGES3, Hsp105 and Bcl-G interacting with AIP in HEK293 cells. The asterisk indicates position of truncated p23 on the gel. ...View More
Bernadotte, A., Kumar, R., Winblad, B., & Pavlov, P. F. (2018). In silico identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network. FEBS Open bio, 8(11), 1830-1843.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0421
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IF, IP

Basic Information

Immunogen
Amino acids 1-300 mapping at the N-terminus of Bcl-G of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BCL2 Like 14
Introduction
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforMouse have been reported for this gene.
Entrez Gene ID
79370
UniProt ID
Q9BZR8
Alternative Names
BCL2 Like 14; BCL2-Like 14 (Apoptosis Facilitator); Bcl2-L-14; BCLG; Apoptosis Facilitator Bcl-2-Like Protein 14; Testicular Tissue Protein Li 26; Apoptosis Regulator BCL-G; Apoptosis Regulator Bcl-G;
Function
Plays a role in apoptosis.
Biological Process
Apoptotic process Source: UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Regulation of apoptotic process Source: Reactome
Regulation of extrinsic apoptotic signaling pathway Source: GO_Central
Cellular Location
Cytoplasm
Isoform 1: Cytosol. Diffusely distributed throughout the cytosol.
Isoform 2: Endomembrane system. Predominantly localized to cytosolic organelles.
PTM
Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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