Mouse Anti-BCL2L14 Recombinant Antibody (CBYY-0420) (CBMAB-0422-YY)

Name: Mouse Anti-BCL2L14 Recombinant Antibody (CBYY-0420)
SKU: CBMAB-0422-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-0420

Application

ELISA, IP, WB

Immunogen

BCL2L14 (AAH25778.1, 1 a.a. ~ 327 a.a) full-length recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

BCL2 Like 14

Introduction

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforMouse have been reported for this gene.

Entrez Gene ID

79370

UniProt ID

Q9BZR8

Alternative Names

BCL2 Like 14; BCL2-Like 14 (Apoptosis Facilitator); Bcl2-L-14; BCLG; Apoptosis Facilitator Bcl-2-Like Protein 14; Testicular Tissue Protein Li 26; Apoptosis Regulator BCL-G; Apoptosis Regulator Bcl-G;

Function

Plays a role in apoptosis.

Biological Process

Apoptotic process Source: UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Regulation of apoptotic process Source: Reactome
Regulation of extrinsic apoptotic signaling pathway Source: GO_Central

Cellular Location

Cytoplasm
Isoform 1: Cytosol. Diffusely distributed throughout the cytosol.
Isoform 2: Endomembrane system. Predominantly localized to cytosolic organelles.

PTM

Phosphorylated by MELK, leading to inhibit its pro-apoptotic function.

Lee, S., Hu, Y., Loo, S. K., Tan, Y., Bhargava, R., Lewis, M. T., & Wang, X. S. (2020). Landscape analysis of adjacent gene rearrangements reveals BCL2L14–ETV6 gene fusions in more aggressive triple-negative breast cancer. Proceedings of the National Academy of Sciences, 117(18), 9912-9921.

Yao, X., Yao, R., Yi, J., & Huang, F. (2019). Upregulation of miR-496 decreases cerebral ischemia/reperfusion injury by negatively regulating BCL2L14. Neuroscience letters, 696, 197-205.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

BCL2L14 Matched Antibody Pair (133) (CAT#: APMAB-133LY)

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BCL2L14 Matched Antibody Pair (133) (CAT#: APMAB-133LY)

Mouse Anti-BCL2L14 Recombinant Antibody (1D11) (CAT#: CBMAB-A0738-LY)

Rabbit Anti-BCL2L14 Recombinant Antibody (CBYY-0425) (CAT#: CBMAB-0427-YY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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