BHLHA15
MIST1 is a basic helix-loop-helix (bHLH) protein that binds to the DNA target sequence CANNTG (E box) present in the promoter or enhancer region of numerous developmentally regulated genes.
Full Name
basic helix-loop-helix family, member a15
Function
Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).
Biological Process
Calcium-mediated signaling Source: Ensembl
Cell-cell signaling Source: Ensembl
Cell maturation Source: Ensembl
Cellular response to glucose starvation Source: UniProtKB
Endoplasmic reticulum unfolded protein response Source: UniProtKB
Glucose homeostasis Source: Ensembl
Golgi organization Source: Ensembl
G protein-coupled receptor signaling pathway Source: Ensembl
Intracellular distribution of mitochondria Source: Ensembl
Mitochondrial calcium ion transmembrane transport Source: Ensembl
Negative regulation of myotube differentiation Source: UniProtKB
Neuron differentiation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cell-cell signaling Source: Ensembl
Cell maturation Source: Ensembl
Cellular response to glucose starvation Source: UniProtKB
Endoplasmic reticulum unfolded protein response Source: UniProtKB
Glucose homeostasis Source: Ensembl
Golgi organization Source: Ensembl
G protein-coupled receptor signaling pathway Source: Ensembl
Intracellular distribution of mitochondria Source: Ensembl
Mitochondrial calcium ion transmembrane transport Source: Ensembl
Negative regulation of myotube differentiation Source: UniProtKB
Neuron differentiation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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Anti-BHLHA15 antibodies
+ Filters

Target: BHLHA15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E7
Application*: WB, E
Target: BHLHA15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYM-0881
Application*: WB, P
Target: BHLHA15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBFYM-0880
Application*: WB, IF, IP, P
Target: BHLHA15
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-0532
Application*: WB, IF, IP, E, P
Target: BHLHA15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBYY-0531
Application*: WB, IF, IP, E, P
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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