BHLHA15

MIST1 is a basic helix-loop-helix (bHLH) protein that binds to the DNA target sequence CANNTG (E box) present in the promoter or enhancer region of numerous developmentally regulated genes.

basic helix-loop-helix family, member a15

Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity).

Calcium-mediated signaling Source: Ensembl
Cell-cell signaling Source: Ensembl
Cell maturation Source: Ensembl
Cellular response to glucose starvation Source: UniProtKB
Endoplasmic reticulum unfolded protein response Source: UniProtKB
Glucose homeostasis Source: Ensembl
Golgi organization Source: Ensembl
G protein-coupled receptor signaling pathway Source: Ensembl
Intracellular distribution of mitochondria Source: Ensembl
Mitochondrial calcium ion transmembrane transport Source: Ensembl
Negative regulation of myotube differentiation Source: UniProtKB
Neuron differentiation Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus